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Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins.
- R. Cramer, D. E. Patterson, J. Bunce
- ChemistryJournal of the American Chemical Society
- 1 August 1988
TLDR
Recent advances in comparative molecular field analysis (CoMFA).
- R. Cramer, D. E. Patterson, J. Bunce
- ChemistryProgress in clinical and biological research
- 1989
Comparative Molecular Field Analysis (CoMFA) has shown predictive performance and versatility that appear to be unprecedented among computer-based techniques for aiding molecular design.
AAA in KAT/DYKAT processes: first- and second-generation asymmetric syntheses of (+)- and (-)-cyclophellitol.
- B. Trost, D. E. Patterson, E. Hembre
- Chemistry, BiologyChemistry
- 3 September 2001
TLDR
Development of a Practical Large-Scale Synthesis of Denagliptin Tosylate
- D. E. Patterson, J. Powers, M. Osterhout
- Chemistry
- 20 August 2009
A large-scale synthesis of denagliptin tosylate has been developed. The efficiency of the synthesis has been improved from the initially scaled route by changing the order of steps (performing a…
Synthesis of 4-Fluoro-β-(4-fluorophenyl)-l-phenylalanine by an Asymmetric Phase-Transfer Catalyzed Alkylation: Synthesis on Scale and Catalyst Stability
- D. E. Patterson, S. Xie, L. A. Jones, M. Osterhout, and Christopher G. Henry, T. Roper
- Chemistry
- 1 May 2007
4-Fluoro-β-(4-fluorophenyl)-l-phenylalanine 1 was synthesized by the asymmetric phase-transfer catalyzed alkylation of tert-butyl glycinate-benzophenone Schiff base using the cinchona alkaloid…
Dynamic Kinetic Asymmetric Transformations of Conduritol B Tetracarboxylates: An Asymmetric Synthesis of d-myo-Inositol 1,4,5-Trisphosphate
- B. Trost, D. E. Patterson, E. Hembre
- Chemistry
- 9 November 1999
Enhanced Enantioselectivity in the Desymmetrization of Meso-Biscarbamates
- B. Trost, D. E. Patterson
- Chemistry
- 4 February 1998
Efficient Asymmetric Synthesis of N-[(1R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-2-pyridinecarboxamide for Treatment of Human Papillomavirus Infections
- Sharon D. Boggs, Jeremy D. Cobb, Xiaoming Zhou
- Chemistry
- 14 February 2007
An efficient asymmetric synthesis of N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-2-pyridinecarboxamide 1, a potential treatment for human papillomavirus infections, is described. The key…
cis‐5‐Amino‐6‐hydroxycyclohexadiene as a Chiral Building Block: An Asymmetric Synthesis of (−)‐Swainsonine
- B. Trost, D. E. Patterson
- Chemistry
- 5 November 1999
The four contiguous stereocenters of (−)-swainsonine were efficiently set in a 15-step synthesis with a 15 % overall yield and >99% ee. In order to differeniate the double bond in the key building…
A convenient route to heteronaphthacenes
- J. Markgraf, D. E. Patterson
- Chemistry
- 1996
Heteronaphthacenes 1 were prepared in two steps from 1,3-dihydrobenzo[c]thiophene 2,2-dioxide (4) and dienophiles 2 via convenient high-temperature Diels-Alder reactions.
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