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Specific suppression of the immune response by HGG tolerant spleen cells. I. Parameters affecting the level of suppression.
TLDR
Evidence in favor of the separation of the tolerant state from suppressive activity is that complete suppression of the normal spleen cell response requires either a high ratio of tolerant to immune competent cells or a delay in the antigenic challenge of the reconstituted recipients.
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Preclinical and clinical development of a dengue recombinant subunit vaccine.
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Advances in flavivirus vaccine development.
TLDR
A review of vaccines for the medically important flaviviruses presents the full spectrum of vaccine options and complexity levels, and provides examples of successes and major challenges.
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Lack of evidence for HIV-2 infection among at-risk individuals in Brazil.
TLDR
It is concluded that caution should be used in the interpretation of serologic cross-reactivity between HIV-1 and HIV-2 and that there is no evidence that HIV- 2 has entered groups at risk for HIV infection in Brazil.
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Polyclonal B lymphocyte activation during Trypanosoma cruzi infection.
Infection of A/J mice with Trypanosoma cruzi results in the polyclonal activation of B lymphocytes in vivo as assessed by the spontaneous plaque-forming cell (PFC) response to trinitrophenyl and to…
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Enhancement of the in vivo antibody response by an 8-derivatized guanine nucleoside.
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Induction and mode of action of suppressor cells generated against human gamma globulin. I. An immunologic unresponsive state devoid of demonstrable suppressor cells
TLDR
Although certain HGG preparations may provide a tool for the generation of antigen-specific suppressor T cells, the utilization of these suppressive preparations may be inappropriate for the investigation of the mechanisms of the induction and maintenance of the unresponsive state.
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Effect of lipopolysaccharide on immunogenicity and tolerogenicity of HGG in C57BL/6J nude mice: evidence for a possible B cell deficiency.
TLDR
The data from several experimental approaches suggested that nude mice may be deficient in a subpopulation of B cells which is responsive to both antigen and nonspecific B cell activators in normal mice.
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Modulation of the induction and circumvention of immunological tolerance to human gamma-globulin by interleukin 1.
TLDR
Results suggest that a signal(s) in addition to those delivered by IL 1 is required for activation of the B cell compartment recovering from tolerance to antibody production, and suggest that the lack of an IL 1 signal may be responsible for the deliverance of a tolerogenic rather than an immunogenic signal to the Th cell.
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Bacterial lipopolysaccharide (endotoxin) interferes with the induction of tolerance and primes thymus-derived lymphocytes.
TLDR
Exposure of antigen-specific helper T and B cells to antigen alone results in the induction of tolerance, whereas induction of immunocompetence in these cells requires at least 2 signals, 1 provided by interaction with antigen and a 2nd delivered by a nonspecific stimulus similar to that provided by LPS in the present experiments.
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