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Determination of the Affinity of Drugs toward Serum Albumin by Measurement of the Quenching of the Intrinsic Tryptophan Fluorescence of the Protein
- D. E. Epps, Thomas J. Raub, V. Caiolfa, A. Chiari, M. Zamai
- Chemistry, Medicine
- The Journal of pharmacy and pharmacology
- 1 January 1999
Binding of new chemical entities to serum proteins is an issue confronting pharmaceutical companies during development of potential therapeutic agents. Most drugs bind to the most abundant plasma… Expand
Inhibition of permeability-dependent Ca2+ release from mitochondria by N-acylethanolamines, a class of lipids synthesized in ischemic heart tissue.
Characterization of the steady-state and dynamic fluorescence properties of the potential-sensitive dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol (Dibac4(3)) in model systems and cells.
The steady-state and dynamic fluorescence properties of the membrane potential-sensitive bis-oxonol dye Dibac4(3) were characterized in vitro using model ligand systems and in vivo in A10 smooth… Expand
Kinetic analysis of the free-radical-induced lipid peroxidation in human erythrocyte membranes: evaluation of potential antioxidants using cis-parinaric acid to monitor peroxidation.
cis-Parinaric acid (PnA), cis-trans-trans-cis-9, 11, 13, 15-octadecatetraenoic acid, is fluorescent (epsilon = 74,000 at 324 nm) when partitioned into a lipid environment and the fluorescence is… Expand
A General, Wide-Range Spectrofluorometric Method for Measuring the Site-Specific Affinities of Drugs toward Human Serum Albumin
Abstract Binding of drugs to serum albumin is one of the most important pharmacokinetic determinants and the design of drugs should take advantage of this property. In the present work, the… Expand
Evidence for transbilayer, tail-to-tail cholesterol dimers in dipalmitoylglycerophosphocholine liposomes.
The behavior of multilamellar liposomes of 2,3-dipalmitoyl-sn-glycero-1-phosphocholine (DPPC) was studied by differential scanning calorimetry (DSC) in the presence of < or = 5 mol % of the… Expand
Spontaneous Aggregation and Cytotoxicity of the β-Amyloid Aβ1–40: A Kinetic Model
The time dependency of the spontaneous aggregation of the fibrillogenic β-Amyloid peptide, Aβ1–40, was measured by turbidity, circular dichroism, HPLC, and fluorescence polarization. The results by… Expand
Altered function of synovial fluid granulocytes in patients with acute inflammatory arthritis
In rheumatoid arthritis (RA) a chronic inflammatory state exists in which the synovial fluid is periodically filled with large numbers of polymorphonuclear leukocytes (PMNs). Oxygen radicals produced… Expand
Acute injections of opiate peptides into the rat cerebral ventricle: A macrophage-like cellular response
Opiate peptides (beta-endorphin, alpha-endorphin or met-enkephalin) were administered to the lateral cerebral ventricle of adult male rats via single injection into implanted cannulas. Scanning EM of… Expand
Cyanamide mediated synthesis under plausible primitive earth conditions
- D. E. Epps, D. Nooner, J. Eichberg, E. Sherwood, J. Oró
- Medicine, Biology
- Journal of Molecular Evolution
- 1 December 1979
SummaryThe formation of glycerol occurs when a solution of DL-glyceraldehyde is heated in the presence of hydrogen sulfide at room temperature. DL-glyceraldehyde and dihydroxyacetone treated with… Expand