• Publications
  • Influence
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration.
  • D. E. Clark
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1 August 1999
This paper describes the derivation of a simple QSAR model for the prediction of log BB from a set of 55 diverse organic compounds. The model contains two variables: polar surface area (PSA) andExpand
  • 429
  • 19
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption.
  • D. E. Clark
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1 August 1999
A method for the rapid computation of polar molecular surface area (PSA) is described. It is shown that consideration of only a single conformer when computing PSA gives an excellent correlation withExpand
  • 497
  • 17
Orthotic Devices for Ambulation in Children with Cerebral Palsy and Myelomeningocele
Children with cerebral palsy and children with myelomeningocele frequently require orthotic devices for standing and walking. The purpose of this article is to review the literature on orthoticExpand
  • 35
Rehabilitation inpatient screening of early cognitive recovery.
A neuropsychologic bedside screening instrument has been developed for use with recovering, cognitively impaired inpatients. Its purpose is to help clarify the nature and extent of cognitiveExpand
  • 18
EMR Hardness Design Guidance
Abstract : This program was conducted to develop the overall methodology, guidelines, procedures, and guidance documentation required to establish an Air Force EMR hardness program for air launchedExpand
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