• Publications
  • Influence
Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel.
ABI-007, an albumin-bound, 130-nm particle form of paclitaxel, was developed to avoid Cremophor/ethanol-associated toxicities in Cremophor-based paclitaxel (Taxol) and to exploit albuminExpand
  • 837
  • 37
  • PDF
Human Tumor Xenograft Models in NCI Drug Development
The methods used by the National Cancer Institute (NCI) for in vivo preclinical development of anticancer drugs were described in detail in the first edition of this book (1). In addition, a seriesExpand
  • 212
  • 11
Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cł.
The enzyme DT-diaphorase (DTD; NAD(P)H:quinone oxidoreductase, EC, is an obligate two electron reductase which catalyzes reduction of a broad range of substrates, including quinones. WeExpand
  • 169
  • 5
Furan-Induced Hepatic Cholangiocarcinomas in Fischer 344 Rats
In a 2-yr carcinogenicity bioassay, 0, 2, 4, or 8 mg furan/kg body weight (BW) was administered to male and female Fischer (F344) rats and resulted in an 86-100% incidence of cholangiocarcinomas withExpand
  • 57
  • 5
2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.
While engaged in therapeutic intervention against a number of proliferative diseases, we have discovered the 2-aminopyrido[2, 3-d]pyrimidin-7(8H)-ones as a novel class of potent, broadly activeExpand
  • 110
  • 4
Toxicity and anticancer activity of a new triazine antifolate (NSC 127755).
A new triazine folate antagonist, 3-chloro-4-((4-(2-chloro-4-[4,6-diamino-2,2-dimethyl-s-triazin-1(2H)-yl]phenyl)butyl)) benzenesulfonyl fluoride compounded with ethanesulfonic acid (1:1) (NSCExpand
  • 73
  • 4
Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts
Purpose: The involvement of the EGF receptor (EGFr) family of receptors in cancers suggests that a selective inhibitor of the tyrosine kinase activity of the EGFr family could have a therapeuticExpand
  • 35
  • 4
Isophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamide.
Isophosphoramide mustard was synthesized and was found to demonstrate activity essentially comparable to cyclophosphamide and ifosfamide against L1210 and P388 leukaemia. Lewis lung carcinoma,Expand
  • 32
  • 3
Encapsulation of the topoisomerase I inhibitor GL147211C in pegylated (STEALTH) liposomes: pharmacokinetics and antitumor activity in HT29 colon tumor xenografts.
The topoisomerase I inhibitor GL147211C [7-[(4-methylpiperazino)methyl]-10,11-(ethylenedioxy)-(20S)-campto thecin trifluoroacetate], a camptothecin analogue, has significant activity in tumor cellExpand
  • 48
  • 3
  • PDF
Response of human tumor xenografts in athymic nude mice to docetaxel (RP 56976, Taxotere®)
SummaryDocetaxel (Taxotere®, RP 56976, NSC 628503), a new taxoid, was evaluated for preclinical evidence of anticancer activity in athymic nude (NCr-nu) mice bearing established, subcutaneouslyExpand
  • 32
  • 2