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Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group.
TLDR
Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health, and finally cancer risk. Expand
Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome
TLDR
An expert panel in PCOS and CVD reviewed literature and presented recommendations, finding women with PCOS with obesity, cigarette smoking, dyslipidemia, hypertension, impaired glucose tolerance, and subclinical vascular disease are at risk, whereas those with metabolic syndrome and/or type 2 diabetes mellitus are at high risk for CVD. Expand
Polycystic ovary syndrome: etiology, pathogenesis and diagnosis
TLDR
Treatment of PCOS is focused on the goals of ameliorating hyperandrogenic symptoms, inducing ovulation and preventing cardiometabolic complications, and ruling out other hyper androgenic or oligo-ovulatory disorders. Expand
Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?
TLDR
Animal models that mimic fetal androgen excess may provide unique insight into the origins of the PCOS syndrome, and the prenatally androgenized female rhesus monkey shows particular relevance to PCOS. Expand
Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome.
TLDR
The pathophysiology involves abnormal gonadotropin secretion from a reduced hypothalamic feedback response to circulating sex steroids, altered ovarian morphology and functional changes, and disordered insulin action in a variety of target tissues. Expand
Consensus on women's health aspects of polycystic ovary syndrome (PCOS).
TLDR
Current knowledge is summarized and knowledge gaps regarding various women's health aspects of PCOS are identified, including adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health and finally cancer risk. Expand
Developmental origin of polycystic ovary syndrome - a hypothesis.
TLDR
It is proposed that the clinical and biochemical features of PCOS can arise as a consequence of genetically determined hypersecretion of androgens by the ovary during, or very likely long before, puberty, and a unifying, 'linear' model is suggested to explain the aetiology of the heterogeneous phenotype. Expand
Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome.
TLDR
Electron beam computed tomography noninvasively measures coronary artery calcium (CAC), a marker for coronary atherosclerosis, and finds that CAC is more prevalent in PCOS women than in obese or nonobese women of similar age. Expand
Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health.
TLDR
Recent technologies are now exploring transcriptional, translational, and post-translational events within the human follicle with the goal of identifying biomarkers that reliably predict oocyte quality in the clinical setting. Expand
Polycystic ovary syndrome and its developmental origins
TLDR
The prenatal testosterone (T)-treated adult female rhesus monkey is one animal model of polycystic ovary syndrome (PCOS) in women, with early prenatal T excess programming a permanent PCOS-like phenotype raising the possibility that T excess in human fetal development promotes PCOS in adulthood. Expand
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