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Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia
TLDR
The study implies that immune-mediated processes are involved in the pathophysiology of achalasia, and fine-mapped a strong MHC association signal by imputing classical HLA haplotypes and amino acid polymorphisms. Expand
Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma--a rationale for a molecular targeting strategy?
TLDR
The results reveal a high rate of receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. Expand
Co-expression of receptor tyrosine kinases in esophageal adenocarcinoma and squamous cell cancer.
TLDR
A high rate of RTK co-expression in esophageal adenocarcinoma and squamous cell cancer is revealed and may encourage application of multi-target RTK inhibitors within a multimodal concept as a promising novel approach for innovative treatment strategies. Expand
PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy.
TLDR
It is revealed that PDGFRalpha/beta expression significantly correlates with lymphatic dissemination and therefore encourages application of PDG FRalpha/ beta RTK-inhibitors within a combination therapy. Expand
Impact of Minimally Invasive Surgery in the Spectrum of Current Achalasia Treatment Options
TLDR
Operative controversies most recently include the length of the myotomy, especially of its fundic part, with respect to the balance between postoperative persistent dysphagia and development of gastroesophageal reflux, as well as the type of the added antireflux procedure. Expand
Expression of chemokine receptor CXCR4 in esophageal squamous cell and adenocarcinoma
TLDR
Evaluating the role of CXCR4 in tumor spread of esophageal cancer with a differentiated view of the two predominant histologic types – squamous cell and adenocarcinoma revealed a poorer long-term prognosis following curative esophagectomy in both histologic subtypes. Expand
PDGFRα/β expression correlates with the metastatic behavior of human colorectal cancer: A possible rationale for a molecular targeting strategy
TLDR
It is revealed that PDGFRalpha/beta expression significantly correlates with lymphatic dissemination and therefore encourages application of PDG FRalpha/ beta RTK-inhibitors within a combination therapy. Expand
VEGF-D Correlates with Metastatic Disease in Gastric Cancer Patients Undergoing Surgery
TLDR
The ligand VEGF-D, rather than the other ligands or tyrosine kinase receptors analyzed, is associated with progressive disease in gastric cancer patients undergoing surgery and might be a helpful marker indicating disseminated disease. Expand
Minimally invasive surgery for achalasia in patients >40 years: more favorable than anticipated
TLDR
Laparoscopic Heller myotomy for achalasia is associated with a high success rate as the primary therapeutic option and after failure of endoscopic therapy and can be performed safely and with favorable outcomes also in patients >40 years, however the long-term durability of the procedure remains to be established. Expand
Murine genetic deficiency of neuronal nitric oxide synthase (nNOS‐/‐) and interstitial cells of Cajal (W/Wv): Implications for achalasia?
TLDR
The function and morphology of the LES in vivo is examined in vivo in NO‐deficient (nNOS‐/‐), ICC‐IM‐ deficient (W/Wv)‐, and wild‐type (WT) mice. Expand
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