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Molecular models of the intercellular lipid lamellae in mammalian stratum corneum.
Intercellular lipid lamellae in the stratum corneum constitute the barrier to water diffusion and may also play a role in cohesion between corneocytes. The lamellae arise from stacks of lamellarExpand
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Lipid organization in pig stratum corneum.
The lipid and keratin structure of pig stratum corneum has been elucidated by small- and wide-angle X-ray diffraction. The measurements were carried out as a function of hydration and temperature. InExpand
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The composition of the ceramides from human stratum corneum and from comedones.
Human epidermal surface lipids were collected by an ethanol wash and the ceramides were quantified by thin-layer chromatography-photodensitometry. Six ceramide fractions were isolated and theExpand
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Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum.
The epidermal permeability barrier necessary for terrestrial life resides in the intercellular spaces of the stratum corneum and is composed of lipids. Membrane coating granules (MCGs), smallExpand
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Age-related changes in sebaceous gland activity.
The sebaceous glands of man show age-related differences in their activity as determined by quantitative and qualitative examination of sebum. Sebaceous secretion is low in children and begins toExpand
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Lipid and protein structures in the permeability barrier of mammalian epidermis.
  • D. Downing
  • Chemistry, Medicine
  • Journal of lipid research
  • 1 March 1992
The epidermis of terrestrial vertebrates has evolved to provide a barrier to water permeation that is essential for survival in a desiccating environment. It has been realized for decades that thisExpand
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Composition and morphology of epidermal cyst lipids.
The contents of epidermal cysts were used as a source of desquamated human keratinocytes uncontaminated by sebaceous, subcutaneous, or bacterial lipids. Lipids extracted with chloroform:methanolExpand
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Covalently bound ω-hydroxyacylsphingosine in the stratum corneum
Pig epidermis was heat separated, and the stratum corneum was isolated after trypsinization. Exhaustive extraction of the stratum corneum fraction with chloroform/methanol mixtures yielded 14.7%Expand
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Photodensitometry in the thin-layer chromatographic analysis of neutral lipids.
  • D. Downing
  • Chemistry, Medicine
  • Journal of chromatography
  • 1968
Abstract A procedure for photodensitometric quantitation of thin-layer chromatograms is described which can give a complete analysis of a mixture of neutral lipids in a single chromatogram withoutExpand
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6-Hydroxy-4-sphingenine in human epidermal ceramides.
The solvent-extractable lipids of human epidermal stratum corneum consist predominantly of ceramides. In addition two non-extractable ceramides are chemically bound to the stratum corneum protein.Expand
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