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HELIQUEST: a web server to screen sequences with specific alpha-helical properties
TLDR
SUMMARY HELIQUEST calculates the physicochemical properties and amino acid composition of an alpha-helix and screens databank to identify protein segments possessing similar features. Expand
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Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers
The yeast Kes1p/Osh4p protein functions as a sterol/PI(4)P exchanger between lipid membranes, which suggests the possibility of creating a sterol gradient via phosphoinositide metabolism.
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Host Cell Invasion by Apicomplexan Parasites: Insights from the Co-Structure of AMA1 with a RON2 Peptide
The structure of a eukaryotic pathogen adhesin bound to its receptor provides a basis for design of therapeutics. Apicomplexan parasites such as Toxoplasma gondii and Plasmodium species activelyExpand
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Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue
Mechanosensitive K+ channels TREK1 and TREK2 form a subclass of two P-domain K+ channels. They are potently activated by polyunsaturated fatty acids and are involved in neuroprotection, anesthesia,Expand
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HELIQUEST : a web server to screen sequences with specific α-helical properties
Summary: HELIQUEST calculates the physicochemical properties and amino acid composition of an α-helix and screens databank to identify protein segments possessing similar features. This server isExpand
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TWIK1, a unique background channel with variable ion selectivity
TWIK1 belongs to the family of background K+ channels with two pore domains. In native and transfected cells, TWIK1 is detected mainly in recycling endosomes. In principal cells in the kidney, TWIK1Expand
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Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities
Cyclophilins are peptidyl-prolyl cis/trans isomerases (PPIase) that catalyse the interconversion of the peptide bond at proline residues. Several cyclophilins play a pivotal role in the life cycle ofExpand
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DOCKGROUND resource for studying protein-protein interfaces
TLDR
The first release of the DOCKGROUND resource implements a comprehensive database of co-crystallized (bound-bound) protein-protein complexes, providing foundation for the upcoming expansion to unbound (experimental and simulated) protein complexes and systematic sets of docking decoys. Expand
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LEA3D: a computer-aided ligand design for structure-based drug design.
We present an improved version of the program LEA developed to design organic molecules. Rational drug design involves finding solutions to large combinatorial problems for which an exhaustive searchExpand
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A genetic algorithm for the automated generation of small organic molecules: Drug design using an evolutionary algorithm
TLDR
Ligand by Evolutionary Algorithm is able to operate directly on the 3D molecular structure for de novo molecular design of new retinoids. Expand
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