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- Publications
- Influence
HELIQUEST: a web server to screen sequences with specific alpha-helical properties
- R. Gautier, D. Douguet, B. Antonny, G. Drin
- Computer Science, Medicine
- Bioinform.
- 15 September 2008
TLDR
Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers
- Maud de Saint-Jean, V. Delfosse, +5 authors G. Drin
- Biology, Medicine
- The Journal of cell biology
- 12 December 2011
The yeast Kes1p/Osh4p protein functions as a sterol/PI(4)P exchanger between lipid membranes, which suggests the possibility of creating a sterol gradient via phosphoinositide metabolism.
Host Cell Invasion by Apicomplexan Parasites: Insights from the Co-Structure of AMA1 with a RON2 Peptide
- M. Tonkin, M. Roques, +5 authors M. Boulanger
- Biology, Medicine
- Science
- 22 July 2011
The structure of a eukaryotic pathogen adhesin bound to its receptor provides a basis for design of therapeutics. Apicomplexan parasites such as Toxoplasma gondii and Plasmodium species actively… Expand
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue
- G. Sandoz, D. Douguet, F. Chatelain, M. Lazdunski, F. Lesage
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 25 August 2009
Mechanosensitive K+ channels TREK1 and TREK2 form a subclass of two P-domain K+ channels. They are potently activated by polyunsaturated fatty acids and are involved in neuroprotection, anesthesia,… Expand
HELIQUEST : a web server to screen sequences with specific α-helical properties
- R. Gautier, D. Douguet, B. Antonny, G. Drin
- 2008
Summary: HELIQUEST calculates the physicochemical properties and amino acid composition of an α-helix and screens databank to identify protein segments possessing similar features. This server is… Expand
- 193
- 11
TWIK1, a unique background channel with variable ion selectivity
- F. Chatelain, D. Bichet, +6 authors F. Lesage
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 19 March 2012
TWIK1 belongs to the family of background K+ channels with two pore domains. In native and transfected cells, TWIK1 is detected mainly in recycling endosomes. In principal cells in the kidney, TWIK1… Expand
Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities
- A. Ahmed-Belkacem, L. Colliandre, +10 authors Jean-François Guichou
- Biology, Medicine
- Nature communications
- 22 September 2016
Cyclophilins are peptidyl-prolyl cis/trans isomerases (PPIase) that catalyse the interconversion of the peptide bond at proline residues. Several cyclophilins play a pivotal role in the life cycle of… Expand
DOCKGROUND resource for studying protein-protein interfaces
- D. Douguet, H. Chen, A. Tovchigrechko, I. Vakser
- Computer Science, Medicine
- Bioinform.
- 1 October 2006
TLDR
LEA3D: a computer-aided ligand design for structure-based drug design.
- D. Douguet, H. Munier-Lehmann, G. Labesse, S. Pochet
- Chemistry, Medicine
- Journal of medicinal chemistry
- 25 February 2005
We present an improved version of the program LEA developed to design organic molecules. Rational drug design involves finding solutions to large combinatorial problems for which an exhaustive search… Expand
A genetic algorithm for the automated generation of small organic molecules: Drug design using an evolutionary algorithm
- D. Douguet, E. Thoreau, G. Grassy
- Computer Science, Medicine
- J. Comput. Aided Mol. Des.
- 1 July 2000
TLDR