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Acquired Immunity to Malaria
TLDR
This review summarizes what is understood about naturally acquired and experimentally induced immunity against malaria with the help of evolving insights provided by biotechnology and places these insights in the context of historical, clinical, and epidemiological observations. Expand
The Complexity of Protective Immunity Against Liver-Stage Malaria1 2
TLDR
Investigation of mechanisms of protective immunity induced by immunization with different vaccine delivery systems in genetically distinct inbred strains, genetically modified mice, and outbred mice establishes that there is a marked diversity of T cell-dependent immune responses that mediate sterile protective immunity against liver-stage malaria. Expand
Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites.
TLDR
These results expand published findings demonstrating that immunization by exposure to thousands of mosquitoes carrying radiation-attenuated Pf sporozoites is safe and well tolerated and elicits strain-transcendent protective immunity that persists for at least 42 weeks. Expand
Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.
TLDR
This first demonstration in healthy naïve humans of the induction of CD8+ C TLs by DNA vaccines, including CTLs that were restricted by multiple HLA alleles in the same individual, provides a foundation for further human testing of this potentially revolutionary vaccine technology. Expand
A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray
TLDR
A protein microarray was developed and used to probe plasma from 220 individuals in Mali and provided insight into patterns of Ab reactivity against Pf proteins based on the life cycle stage at which proteins are expressed, subcellular location, and other proteomic features, which could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf. Expand
Profiling humoral immune responses to P. falciparum infection with protein microarrays
TLDR
Using malaria as a model, a method is reported which elucidates the profile of antibodies that develop after natural or experimental infection or after vaccination with attenuated organisms, and which identifies immunoreactive antigens of interest for vaccine development or other applications. Expand
Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus
TLDR
It is shown that identical TCR protein sequences are used by clones from each of four healthy unrelated virus carriers; a clone from a fifth varied conservatively at only two residues, suggesting that a persistent viral infection can select for a highly focused memory response and indicates a strong bias in gene segment usage and recombination. Expand
Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles.
TLDR
Data validate the concept of HLA supertypes at the biological level, show that highly degenerate peptides are almost always recognized as epitopes, and demonstrate the feasibility of developing a universally effective vaccine by focusing on a limited number of peptide specificities. Expand
Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon gamma-, and nitric oxide-dependent immunity
TLDR
It is reported that immunization with plasmid DNA encoding the plasmodium yoelii circumsporozoite protein protected one of five strains of mice against malaria and introduced a new target of protective preerythrocytic immune responses, PyHEP 17 and its P. falciparum homologue. Expand
Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data
TLDR
The data suggest that immune responses to Plasmodium are dispersed on a relatively large number of parasite antigens, which has implications for the understanding of immunodominance and breadth of responses to complex pathogens. Expand
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