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Scientific Opinion on Arsenic in Food 1 EFSA Panel on Contaminants in the Food Chain ( CONTAM )
Arsenic is a metalloid that occurs in different inorganic and organic forms, which are found in the environment both from natural occurrence and from anthropogenic activity. The inorganic forms of…
Degradation of Phenanthrene and Anthracene by Cell Suspensions of Mycobacterium sp. Strain PYR-1
- J. Moody, J. Freeman, D. Doerge, C. Cerniglia
- ChemistryApplied and Environmental Microbiology
- 1 April 2001
The data point to the existence, next to already known routes for both gram-negative and gram-positive bacteria, of alternative pathways that might be due to the presence of different dioxygenases or to a relaxed specificity of the same dIOxygenase for initial attack on polycyclic aromatic hydrocarbons.
Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors…
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
PAC-1 is the first small molecule known to directly activate procaspase-3 to caspases, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery.
Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposure.
- J. Teeguarden, A. Calafat, Morgan Graham
- MedicineToxicological sciences : an official journal of…
- 1 September 2011
During these high dietary exposures, (TOT)BPA concentrations in serum were undetectable in 83% of the 320 samples collected and BPA concentrations were determined to be less than or equal to LOD in all samples.
Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometry.
- D. Doerge, H. C. Chang, M. Churchwell, C. L. Holder
- Chemistry, BiologyDrug metabolism and disposition: the biological…
- 1 March 2000
A prominent role for glucuronidation of genistein in the intestine concomitant with absorption is suggested, although hepatic glucuronidated of absorbed geniste in and daidzein aglycones is also likely.
Pharmacokinetics of bisphenol A in humans following a single oral administration.
Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts.
- B. Ghanayem, L. P. McDaniel, D. Doerge
- Biology, MedicineToxicological sciences : an official journal of…
- 1 December 2005
It is demonstrated that CYP2E1 is the primary enzyme responsible for the epoxidation of AA to GA, which leads to the formation of GA-DNA and HGB adducts.
DNA adducts derived from administration of acrylamide and glycidamide to mice and rats.