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The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation.
It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Microcomputer analyses of performance on a portable, simple visual RT task during sustained operations
A microcomputer software system is developed that inputs, edits, transforms, analyzes, and reduces the data from the RT portable audiotapes, for each 10-min trial on the task.
Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night.
It is suggested that cumulative nocturnal sleep debt had a dynamic and escalating analog in cumulative daytime sleepiness and that asymptotic or steady-state sleepiness was not achieved in response to sleep restriction.
Sleep Deprivation and Vigilant Attention
PVT results during extended periods of wakefulness reveal the presence of interacting circadian and homeostatic sleep drives and the interplay of “top‐down” and “bottom‐up” attention in producing the unstable and unpredictable patterns of behavior that are the hallmark of the sleep‐deprived state.
Neurocognitive consequences of sleep deprivation.
Performance deficits associated with sleep disorders are often viewed as a simple function of disease severity; however, recent experiments suggest that individual vulnerability to sleep loss may play a more critical role than previously thought.
Maximizing sensitivity of the psychomotor vigilance test (PVT) to sleep loss.
Using both sensitive PVT metrics and optimal test durations maximizes the sensitivity of the PVT to sleep loss and therefore potentially decreases the sample size needed to detect the same neurobehavioral deficit and proposes criteria to better standardize the 10-min PVT.
Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress.
- Jiongjiong Wang, H. Rao, J. Detre
- Psychology, BiologyProceedings of the National Academy of Sciences…
- 6 December 2005
The results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress response.
Behavioral and physiological consequences of sleep restriction.
Recent experiments reveal that following days of chronic restriction of sleep duration below 7 hours per night, significant daytime cognitive dysfunction accumulates to levels comparable to that found after severe acute total sleep deprivation.
A meta-analysis of the impact of short-term sleep deprivation on cognitive variables.
Of several moderators tested, only time awake was a significant predictor of between-studies variability, and only for accuracy measures, suggesting that heterogeneity in test characteristics may account for a significant amount of the remaining between-study variance.
Sustained attention performance during sleep deprivation: evidence of state instability.
The marked increases in PVT performance variability as sleep loss continued supports the "state instability" hypothesis, which posits that performance during sleep deprivation is increasingly variable due to the influence of sleep initiating mechanisms on the endogenous capacity to maintain attention and alertness, thereby creating an unstable state that fluctuates within seconds.