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Structure of a V3-Containing HIV-1 gp120 Core
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding, which provides a structural rationale for the role of V3 in HIV entry and neutralization.
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.
Structural definition of a conserved neutralization epitope on HIV-1 gp120
A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1.
Evaluation of gene expression measurements from commercial microarray platforms.
Correlations in gene expression levels and comparisons for significant gene expression changes in this subset were calculated, and showed considerable divergence across the different platforms, suggesting the need for establishing industrial manufacturing standards, and further independent and thorough validation of the technology.
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy
These results are the first to establish the clinical activity of a CD22-CAR in B-all, including leukemia resistant to anti-CD19 immunotherapy, demonstrating potency against B-ALL comparable to that of CD19-CAR at biologically active doses.
Evidence for Cell-Surface Association Between Fusin and the CD4-gp120 Complex in Human Cell Lines
- C. Lapham, J. Ouyang, B. Chandrasekhar, N. Nguyen, D. Dimitrov, H. Golding
- 25 October 1996
Evidence for physical association between fusin and the CD4-gp120 complex on cell membranes is provided and it is shown that infection of 3T3.401 cells with vaccinia-fusin recombinant virus (vCBYF1), followed by gp120 treatment, resulted in coprecipitation of fus in and CD4.401 molecules from their membranes.
HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression.
- R. Davey, N. Bhat, H. Lane
- Medicine, BiologyProceedings of the National Academy of Sciences…
- 21 December 1999
Ex vivo labeling with BrdUrd showed that CD4 and CD8 cell turnover increased after withdrawal of HAART and correlated with viral load whereas lymphocyte turnover decreased after reinitiation of drug treatment, and Virologic relapse occurs rapidly in patients who discontinue suppressive drug therapy.
The SARS-CoV S glycoprotein: expression and functional characterization
Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia.
It is concluded that second-generation m971 mAb-derived anti-CD22 CARs are promising novel therapeutics that should be tested in BCP-ALL.