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- Publications
- Influence
Structure of a V3-Containing HIV-1 gp120 Core
- Chih-chin Huang, M. Tang, +9 authors P. Kwong
- Biology, Medicine
- Science
- 11 November 2005
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of… Expand
Structural definition of a conserved neutralization epitope on HIV-1 gp120
The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement of the gp120 glycoprotein… Expand
Evaluation of gene expression measurements from commercial microarray platforms.
- Paul K Tan, T. Downey, +6 authors M. Cam
- Biology, Medicine
- Nucleic acids research
- 1 October 2003
Multiple commercial microarrays for measuring genome-wide gene expression levels are currently available, including oligonucleotide and cDNA, single- and two-channel formats. This study reports on… Expand
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy
- T. Fry, N. Shah, +21 authors C. Mackall
- Medicine
- Nature Medicine
- 2018
Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent effects in relapsed and/or refractory pre–B cell acute lymphoblastic leukemia (B-ALL), but antigen loss is a frequent cause of… Expand
A mechanism of liposome electroformation
- M. Angelova, D. Dimitrov
- Chemistry
- 1988
External electric fields can induce or prevent liquid swelling and liposome formation on solid surfaces. These effects depend on the type of lipid and surface, the medium parameters (temperature,… Expand
The SARS-CoV S glycoprotein: expression and functional characterization
- X. Xiao, S. Chakraborti, A. Dimitrov, K. Gramatikoff, D. Dimitrov
- Biology, Medicine
- Biochemical and Biophysical Research…
- 27 November 2003
Abstract
We have cloned, expressed, and characterized the full-length and various soluble fragments of the SARS-CoV (Tor2 isolate) S glycoprotein. Cells expressing S fused with… Expand
Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia.
- Waleed M. Haso, D. Lee, +10 authors R. Orentas
- Biology, Medicine
- Blood
- 14 February 2013
Immune targeting of B-cell malignancies using chimeric antigen receptors (CARs) is a promising new approach, but critical factors impacting CAR efficacy remain unclear. To test the suitability of… Expand
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.
- Chih-chin Huang, M. Venturi, +11 authors P. Kwong
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 2 March 2004
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and… Expand
Evidence for Cell-Surface Association Between Fusin and the CD4-gp120 Complex in Human Cell Lines
- C. Lapham, J. Ouyang, B. Chandrasekhar, N. Y. Nguyen, D. Dimitrov, H. Golding
- Biology, Medicine
- Science
- 25 October 1996
Accessory cell-surface molecules involved in the entry of human immunodeficiency virus-type 1 into cells have recently been identified and shown to belong to the family of chemokine receptors.… Expand
Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody*
- P. Prabakaran, J. Gan, +5 authors D. Dimitrov
- Biology, Medicine
- Journal of Biological Chemistry
- 9 June 2006
The severe acute respiratory syndrome coronavirus (SARS-CoV, or SCV), which caused a world-wide epidemic in 2002 and 2003, binds to a receptor, angiotensin-converting enzyme 2 (ACE2), through the… Expand
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