Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 receptor ligand.
Modification of behavioral effects of drugs in mice by neuroactive steroids
- J. T. Ungard, M. Beekman, M. Gasior, R. Carter, D. Dijkstra, J. Witkin
- Biology, PsychologyPsychopharmacology
- 1 March 2000
The present findings support the unique pharmacological effects of neuroactive steroids as a novel class of positive allosteric modulators of GABA.
Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.
A number of the 2-aminotetralins showed high affinity for both the D2 and the D3 DA receptors, as exemplified by compounds 11-15 and 21-26, while some had a reasonable selectivity for the DA D3 receptors.
Central administration of dopamine D3 receptor antisense to rat: effects on locomotion, dopamine release and [3H]spiperone binding
- A. Ekman, H. Nissbrandt, M. Heilig, D. Dijkstra, E. Eriksson
- BiologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 1 September 1998
It is concluded that the antisense strategy is useful for investigating the functional role of dopamine D3 receptors and that the dopamine D 3 receptor is involved in rat locomotor behaviour.
Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cells.
Further characterization of structural requirements for ligands at the dopamine D(2) and D(3) receptor: exploring the thiophene moiety.
- D. Dijkstra, N. Rodenhuis, E. S. Vermeulen, T. Pugsley, L. Wise, H. Wikström
- Chemistry, BiologyJournal of medicinal chemistry
- 4 July 2002
The present study describes the synthesis and in vitro pharmacology of a novel series of dopaminergic agents in which the classical phenylethylamine pharmacophore is replaced by a thienylethyamine moiety, which showed a moderate affinity for the dopamine D(2) and D(3) receptors.
Dopamine D(2) activity of R-(-)-apomorphine and selected analogs: a microdialysis study.
Autoradiographic localisation of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907
The new compound [3H]PD 128907 appears to be a suitable radioligand for autoradiographic examination of the D3-dopamine receptor localisation in the human brain, and should also be useful for pharmacological studies of this receptor subtype.
The membrane-bound domain of the phosphotransferase enzyme IImtl of Escherichia coli constitutes a mannitol translocating unit.
- J. Lolkema, D. Dijkstra, R. H. ten Hoeve-Duurkens, G. Robillard
- Biology, ChemistryBiochemistry
- 27 November 1990
These experiments indicate that the translocation of mannitol is catalyzed by the membrane-bound N-terminal half of enzyme IImtl which is a structurally stable domain.