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Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 receptor ligand.
Modification of behavioral effects of drugs in mice by neuroactive steroids
The present findings support the unique pharmacological effects of neuroactive steroids as a novel class of positive allosteric modulators of GABA.
Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.
A number of the 2-aminotetralins showed high affinity for both the D2 and the D3 DA receptors, as exemplified by compounds 11-15 and 21-26, while some had a reasonable selectivity for the DA D3 receptors.
Central administration of dopamine D3 receptor antisense to rat: effects on locomotion, dopamine release and [3H]spiperone binding
It is concluded that the antisense strategy is useful for investigating the functional role of dopamine D3 receptors and that the dopamine D 3 receptor is involved in rat locomotor behaviour.
Further characterization of structural requirements for ligands at the dopamine D(2) and D(3) receptor: exploring the thiophene moiety.
The present study describes the synthesis and in vitro pharmacology of a novel series of dopaminergic agents in which the classical phenylethylamine pharmacophore is replaced by a thienylethyamine moiety, which showed a moderate affinity for the dopamine D(2) and D(3) receptors.
Autoradiographic localisation of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907
The new compound [3H]PD 128907 appears to be a suitable radioligand for autoradiographic examination of the D3-dopamine receptor localisation in the human brain, and should also be useful for pharmacological studies of this receptor subtype.
The membrane-bound domain of the phosphotransferase enzyme IImtl of Escherichia coli constitutes a mannitol translocating unit.
These experiments indicate that the translocation of mannitol is catalyzed by the membrane-bound N-terminal half of enzyme IImtl which is a structurally stable domain.
Assessment of cocaine-like discriminative stimulus effects of dopamine D3 receptor ligands.