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Effects of Flavoring and Casing Ingredients on the Toxicity of Mainstream Cigarette Smoke in Rats
TLDR
The results did not indicate any consistent differences in toxicologic effects between smoke from cigarettes containing the flavoring or casing ingredients and reference cigarettes.
Morphological, pharmacokinetic, and hematological studies of lead-exposed pigeons.
TLDR
Lead exposure induced a marked and rapid hypochromic normocytic anemia in these birds, as well as an elevation in erythrocyte porphyrin, and hematological effects of lead, the major systemic evidence of toxicity.
Toxicity studies of acetone administered in the drinking water of rodents.
TLDR
The effects of acetone were either subtle in nature or occurred during very high levels of exposure confirming acetone's low level of toxicity, and resembled those seen during the clinical condition of megaloblastic anemia.
Subchronic toxicity of barium chloride dihydrate administered to rats and mice in the drinking water.
TLDR
Serum sodium, potassium, and calcium levels in rats were unchanged by barium treatment, as were hematological values, and in both species at 4000 ppm, motor activity, grip strength, and thermal sensitivity were marginally affected.
Effects of chronic lead administration on acquisition and performance of serial position sequences by pigeons.
TLDR
Male White Carneaux pigeons trained to peck three illuminated response keys in a predetermined four-step position sequence are suggested to be more sensitive to the effects of lead than the less stable error rates maintained under the acquisition schedule.
Subchronic toxicity of barium Chloride dihydrate administered to rats and mice in the drinking water
Barium Chloride dihydrate (BaCl2.2H2O) was given for 92 days to B6C3F1 mice and Fischer 344/N rats in their drinking water at levels of 0, 125, 500, 1000, 2000, and 4000 ppm. The no-effect level for
Subchronic (13-week) toxicity studies of oral phenolphthalein in Fischer 344 rats and B6C3F1 mice.
TLDR
Although there were no effects on body weight gain, elevated liver weights were noted in female mice receiving 6000–50,000 ppm phenolphthalein, the primary treatment-related findings that occurred during the mouse studies involved the reproductive and hematopoietic systems.
Comparative Toxicity and Carcinogenicity Studies of Tetracycline and Oxytetracycline in Rats and Mice
TLDR
The notion that neither antibiotic is carcinogenic in rodents is supported, with several negative trends suggesting possible protective effects by both these tetracycline analogs against certain spontaneous neoplastic and non-neoplastic changes.
Effects of lead on temporally-spaced responding in rats.
TLDR
The effects of lead acetate and aging on temporally-spaced responding (differential reinforcement of low rate or DRL-20 seconds) were studied and lead-treated animals exhibited a more variable response to d-amphetamine and a more pronounced number of IRTs in the first class interval.
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