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Age-dependent fate and lineage restriction of single NG2 cells
NG2-expressing glia (NG2 cells, polydendrocytes) appear in the embryonic brain, expand perinatally, and persist widely throughout the gray and white matter of the mature central nervous system. WeExpand
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Vesicular glutamate release from axons in white matter
Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contactExpand
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The Fate of Synaptic Input to NG2 Glial Cells: Neurons Specifically Downregulate Transmitter Release onto Differentiating Oligodendroglial Cells
NG2-expressing oligodendrocyte precursor cells (OPCs) are ubiquitous and generate oligodendrocytes throughout the young and adult brain. Previous work has shown that virtually every NG2 cell receivesExpand
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A novel mechanism underlying drug resistance in chronic epilepsy
The development of resistance to pharmacological treatment is common to many human diseases. In chronic epilepsy, many patients develop resistance to anticonvulsant drug treatment during the courseExpand
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Endogenous Ca2+ Buffer Concentration and Ca2+ Microdomains in Hippocampal Neurons
Ca2+-binding proteins are ubiquitously expressed throughout the CNS and serve as valuable immunohistochemical markers for certain types of neurons. However, the functional role of most Ca2+-bindingExpand
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Functional Specialization of Presynaptic Cav2.3 Ca2+ Channels
Ca2+ influx into presynaptic terminals via voltage-dependent Ca2+ channels triggers fast neurotransmitter release as well as different forms of synaptic plasticity. Using electrophysiological andExpand
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Glial cells are born with synapses
In postnatal rodent brain, certain NG2‐expressing oligodendroglial precursor cells (OPCs) are contacted by synaptic terminals from local neurons. However, it has remained elusive whether and whenExpand
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Stability, affinity and chromatic variants of the glutamate sensor iGluSnFR
Single-wavelength fluorescent reporters allow visualization of specific neurotransmitters with high spatial and temporal resolution. We report variants of intensity-based glutamate-sensingExpand
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Synapses on NG2‐expressing progenitors in the brain: multiple functions?
Progenitor cells expressing the proteoglycan NG2 represent approximately 5% of the total cells in the adult brain, and are found both in grey and white matter regions where they give rise toExpand
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Nanodomains of Single Ca2+ Channels Contribute to Action Potential Repolarization in Cortical Neurons
The precise shape of action potentials in cortical neurons is a key determinant of action potential-dependent Ca2+ influx, as well as of neuronal signaling, on a millisecond scale. In corticalExpand
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