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The stressed hippocampus, synaptic plasticity and lost memories
TLDR
An overview of the neurobiology of stress–memory interactions is provided, and a neural–endocrine model is presented to explain how stress modifies hippocampal functioning.
The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law
TLDR
It is proposed that with the onset of strong emotionality, the hippocampus rapidly shifts from a “configural/cognitive map” mode to a ‘flashbulb memory’ mode, which underlies the long-lasting, but fragmented, nature of traumatic memories.
Inverted‐U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation
TLDR
Findings provide strong support for the hypothesis that corticosterone exerts a concentration‐dependent biphasic influence on the expression of hippocampal plasticity.
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
TLDR
It is shown that vaccination with Aβ protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease and may prevent and, possibly, treat Alzheimer's dementia.
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.
TLDR
It is shown that vaccination with A beta protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease and may prevent and, possibly, treat Alzheimer's dementia.
Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice
TLDR
The RAWM has the spatial complexity and performance measurement simplicity of the dry radial arm maze combined with the rapid learning and strong motivation observed in the Morris water maze without requiring foot shock or food deprivation as motivating factors.
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