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Modulation of Glutamate Mobility Reveals the Mechanism Underlying Slow-Rising AMPAR EPSCs and the Diffusion Coefficient in the Synaptic Cleft
Fast- and slow-rising AMPA receptor-mediated EPSCs occur at central synapses. Fast-rising EPSCs are thought to be mediated by rapid local release of glutamate. However, two controversial mechanismsExpand
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Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor
The immunoregulatory proteins C-C chemokines are potent chemoattractants of lymphocytes and monocytes, as well as activators and attractants of eosinophils and basophils. We have isolated a cDNA thatExpand
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Spillover of Glutamate onto Synaptic AMPA Receptors Enhances Fast Transmission at a Cerebellar Synapse
Diffusion of glutamate from the synaptic cleft can activate high-affinity receptors, but is not thought to contribute to fast AMPA receptor-mediated transmission. Here, we show that single AMPAExpand
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Changes in synaptic structure underlie the developmental speeding of AMPA receptor–mediated EPSCs
At many excitatory and inhibitory synapses throughout the nervous system, postsynaptic currents become faster as the synapse matures, primarily owing to changes in receptor subunit composition. TheExpand
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Nanoscale Distribution of Presynaptic Ca2+ Channels and Its Impact on Vesicular Release during Development
Summary Synaptic efficacy and precision are influenced by the coupling of voltage-gated Ca2+ channels (VGCCs) to vesicles. But because the topography of VGCCs and their proximity to vesicles isExpand
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Synaptic diversity enables temporal coding of coincident multi-sensory inputs in single neurons
The ability of the brain to rapidly process information from multiple pathways is critical for reliable execution of complex sensory-motor behaviors, yet the cellular mechanisms underlying a neuronalExpand
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Rapid Vesicular Release, Quantal Variability, and Spillover Contribute to the Precision and Reliability of Transmission at a Glomerular Synapse
The amplitude and shape of EPSC waveforms are thought to be important determinants of information processing and storage in the brain, yet relatively little is known about the origins of EPSCExpand
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Holographic photolysis of caged neurotransmitters
Stimulation of light-sensitive chemical probes has become a powerful tool for the study of dynamic signaling processes in living tissue. Classically, this approach has been constrained by limitationsExpand
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A Role for Synaptic Input Distribution in a Dendritic Computation of Motion Direction in the Retina
The starburst amacrine cell in the mouse retina presents an opportunity to examine the precise role of sensory input location on neuronal computations. Using visual receptive field mapping, glutamateExpand
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Ca2+ Channel to Synaptic Vesicle Distance Accounts for the Readily Releasable Pool Kinetics at a Functionally Mature Auditory Synapse
Precise regulation of synaptic vesicle (SV) release at the calyx of Held is critical for auditory processing. At the prehearing calyx of Held, synchronous and asynchronous release is mediated by fastExpand
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