D. Denys

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Obsessive-compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM-V.

James F. Leckman, D. Denys, +8 authors D. J. Stein
Depression and anxiety
2010

BACKGROUND Since the publication of the DSM-IV in 1994, research on obsessive-compulsive disorder (OCD) has continued to expand. It is timely to reconsider the nosology of this disorder, assessing… (More)

Subthreshold symptoms and obsessive-compulsive disorder: evaluating the diagnostic threshold

Carla de Bruijn, Stacey Beun, Ron De Graaf, Margreet Ten Have, D. Denys
Psychological medicine
2010

BACKGROUND In this study we compared subjects with obsessive and/or compulsive symptoms who did not meet all criteria for obsessive-compulsive disorder (OCD) (subthreshold subjects) to subjects with… (More)

Should OCD be classified as an anxiety disorder in DSM-V?

Dan J. Stein, Naomi Anne Fineberg, +6 authors Katharine A. Phillips
Depression and anxiety
2010

In DSM-III, DSM-III-R, and DSM-IV, obsessive-compulsive disorder (OCD) was classified as an anxiety disorder. In ICD-10, OCD is classified separately from the anxiety disorders, although within the… (More)

Genome-wide association study of obsessive-compulsive disorder

S. Evelyn Stewart, Xinlin Yu, +106 authors David L. Pauls
Molecular Psychiatry
2013

Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness with complex genetic etiology. The International OCD Foundation Genetics Collaborative (IOCDF-GC) is a… (More)

Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine

D. Denys, André A. Klompmakers, Herman G. M. Westenberg
Psychopharmacology
2004

The combination of atypical antipsychotic drugs in addition to serotonin reuptake inhibitors has recently proven to be beneficial in a number of neuropsychiatric disorders, such as major depression,… (More)

Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report.

M. Mantione, Wim van de Brink, P. R. Schuurman, D. Denys
Neurosurgery
2010

OBJECTIVE Smoking and overeating are compulsory habits that are difficult to stop. Several studies have shown involvement of the nucleus accumbens in these and other addictive behaviors. In this case… (More)

Sexual pleasure in women with obsessive-compulsive disorder?

Nienke C. C. Vulink, D. Denys, Léonie Bus, Herman G. M. Westenberg
Journal of affective disorders
2006

BACKGROUND Although patients with OCD have reported sexual dissatisfaction frequently, controlled studies are sparse. This study compared subjective appreciation of sexuality and sexual functioning… (More)

Female hormones affect symptom severity in obsessive-compulsive disorder.

Nienke C. C. Vulink, D. Denys, Léonie Bus, Herman G. M. Westenberg
International clinical psychopharmacology
2006

There is circumstantial evidence that reproductive events can influence symptom severity of obsessive-compulsive disorder (OCD). We sent self-report questionnaires to 350 female outpatients with OCD… (More)

Think twice: Impulsivity and decision making in obsessive–compulsive disorder

Giacomo Grassi, Stefano Pallanti, +6 authors Paolo Stratta
Journal of behavioral addictions
2015

BACKGROUND AND AIMS Recent studies have challenged the anxiety-avoidance model of obsessive-compulsive disorder (OCD), linking OCD to impulsivity, risky-decision-making and reward-system dysfunction,… (More)

Lipopolysaccharide-induced cytokine production in obsessive–compulsive disorder and generalized social anxiety disorder

Sjoerd B. A. H. A. Fluitman, D. Denys, Nienke C. C. Vulink, Sara I J Schutters, Herman G. M. Westenberg
Psychiatry Research
2010

The immune system is implicated in the pathophysiology of various psychiatric disorders. In anxiety disorders such as obsessive-compulsive disorder (OCD) and generalized social anxiety disorder… (More)

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