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Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder.
TLDR
Bilateral deep brain stimulation of the nucleus accumbens may be an effective and safe treatment for treatment-refractory OCD and no permanent adverse events were reported. Expand
Misophonia: Diagnostic Criteria for a New Psychiatric Disorder
TLDR
It is suggested that misophonia should be classified as a discrete psychiatric disorder and diagnostic criteria could help to officially recognize the patients and the disorder, improve its identification by professional health carers, and encourage scientific research. Expand
Analysis of shared heritability in common disorders of the brain
TLDR
It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Expand
Obsessive–compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM‐V
TLDR
A number of changes to the existing diagnostic criteria for OCD are proposed, and these proposed criteria may change as the DSM‐V process progresses. Expand
Dysfunctional Reward Circuitry in Obsessive-Compulsive Disorder
TLDR
This first functional imaging study to investigate explicitly reward circuitry in OCD shows attenuated reward anticipation activity in the nucleus accumbens compared with healthy control subjects, and supports the conceptualization of OCD as a disorder of reward processing and behavioral addiction. Expand
Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response
TLDR
It is confirmed that DBS constitutes a valid alternative to lesional surgery for severe, therapy-refractory OCD patients and well-controlled, randomized studies with larger samples are needed to establish the optimal targeting and stimulation conditions. Expand
Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder
TLDR
In vivo evidence for abnormalities in the binding potential of the dopamine D(2) receptor is provided, which suggest the direct involvement of the dopaminergic system in the pathophysiology of OCD. Expand
Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder
TLDR
It is found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Expand
Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates
TLDR
The results support the utility of both OCD diagnosis and symptom dimensions in genetic research and clinical contexts and both shared and unique genetic influences underlie susceptibility to OCD and its symptom dimensions. Expand
New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity
TLDR
New developments in the investigation of the neurocognition of impulsivity and compulsivity in humans are reviewed in order to advance the understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research. Expand
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