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Proneural genes in neocortical development
TLDR
Current efforts to better understand how proneural gene function is regulated will not only improve the understanding of neocortical development, but are also critical to the future development of regenerative therapies for the treatment of neuronal degeneration or disease. Expand
bHLH transcription factors in neural development, disease, and reprogramming
TLDR
The powerful ability of bHLH factors to direct neuronal and glial cell fate specification and differentiation has been exploited in the relatively new field of cellular reprogramming, in which pluripotent stem cells or somatic stem cells are converted to neural lineages, often with a transcription factor-based lineage conversion strategy that includes one or more of the b HLH genes. Expand
Neurog1 and Neurog2 coordinately regulate development of the olfactory system
TLDR
It is concluded that Neurog1/2 together coordinate development of the olfactory system, which depends on tissue interactions between the Olfactory bulb and epithelium, and a cell autonomous role for Neurog 1/ 2 in specifying the glutamatergic identity of olfFactory bulb neurons is identified. Expand
Neurog1 and Neurog2 Control Two Waves of Neuronal Differentiation in the Piriform Cortex
TLDR
This work shows that in mouse, the proneural genes Neurog1 and Neurog2 are coexpressed in the ventral pallium, a progenitor pool that first gives rise to Cajal-Retzius cells, and later to layer II/III neurons of the piriform cortex. Expand
A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis
TLDR
It is found that Neurog1 acts in an atypical fashion as it is required to suppress rather than promote neuronal differentiation in early corticogenesis, and employs different mechanisms to temper the pace of early neocortical neurogenesis. Expand
Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex
TLDR
It is revealed that the proneural genes Neurog2 and Ascl1, which are together expressed in neocortical progenitors, cooperate to regulate the expression of components of the cortical derepression circuit to specify corticothalamic and subcerebral identities while repressing a callosal fate. Expand
Forebrain neurogenesis: From embryo to adult.
TLDR
A satellite symposium to the Canadian Developmental Biology Conference 2016 was held on March 16-17, 2016 in Banff, Alberta, Canada, entitled Forebrain Neurogenesis: From embryo to adult, bringing together the top Canadian and international researchers in the field. Expand