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Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity.
TLDR
Recent insights into the role of the PD-1/PD-L1 pathway in regulating lymphocyte activation, promotion of T regulatory cell development and function, breakdown of tolerance and development of autoimmunity are presented. Expand
Mechanisms of the anti‐inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways
TLDR
Several functional interactions between GCs and MAPK signaling have been discovered and studied and their potential biological relevance in mediating the anti‐inflammatory effects of GCs are reviewed. Expand
Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice.
TLDR
The hypothesis that GILZ participates in the regulation of thymocyte apoptosis by glucocorticoids is supported. Expand
Inhibited cell death, NF-kappaB activity and increased IL-10 in TCR-triggered thymocytes of transgenic mice overexpressing the glucocorticoid-induced protein GILZ.
TLDR
The hypothesis that GILZ regulates, at least in part, T-cell development by influencing thymus function at cellular and molecular levels is supported. Expand
CD2 rescues T cells from T-cell receptor/CD3 apoptosis: a role for the Fas/Fas-L system.
TLDR
It is shown that CD2 stimulation inhibits apoptosis by preventing the CD3-induced upregulation of Fas and Fas-L in a Fas-dependent experimental system, suggesting that a costimulatory molecule may control a deletion pathway and may therefore contribute to the regulation of peripheral tolerance. Expand
Cloning and expression of a short Fas ligand: A new alternatively spliced product of the mouse Fas ligand gene.
TLDR
RNase protection and immunoprecipitation analysis showed that FasLs is expressed in nonactivated normal spleen cells and in hybridoma T cells and that it is upregulated upon activation by anti-CD3 monoclonal antibody (MoAb). Expand
Survival of a neglected case of brain abscess caused by Cladophialophora bantiana.
TLDR
A case of a patient who survived a recurrent cerebral abscess caused by C. bantiana despite delayed and apparently inappropriate therapy is reported. Expand
Role of CD44 in the development of natural killer cells from precursors in long-term cultures of mouse bone marrow.
TLDR
Results indicate that interaction of CD44 with HA plays an important role in the development of pre-NK cells into cytotoxic effector cells. Expand
Identification of three novel mRNA splice variants of GITR
GITR is a gene belonging to the nerve growth factor-tumor necrosis factor receptor (NGF/TNFR) family that is preferentially expressed in lymphoid tissues, is overexpressed following dexamethasoneExpand
Gene structure and chromosomal assignment of mouse GITR, a member of the tumor necrosis factor/nerve growth factor receptor family.
TLDR
Results indicate that GITR shares several features with OX40, 4-1BB, and CD27, suggesting the existence of a new subfamily of the TNFR family, as also confirmed by the similarity of their cytoplasmic domains. Expand
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