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Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity.
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Mechanisms of the anti‐inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways
TLDR
Several functional interactions between GCs and MAPK signaling have been discovered and studied and their potential biological relevance in mediating the anti‐inflammatory effects of GCs are reviewed.
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Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice.
TLDR
The hypothesis that GILZ participates in the regulation of thymocyte apoptosis by glucocorticoids is supported.
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CD2 rescues T cells from T-cell receptor/CD3 apoptosis: a role for the Fas/Fas-L system.
TLDR
It is shown that CD2 stimulation inhibits apoptosis by preventing the CD3-induced upregulation of Fas and Fas-L in a Fas-dependent experimental system, suggesting that a costimulatory molecule may control a deletion pathway and may therefore contribute to the regulation of peripheral tolerance.
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Inhibited cell death, NF-kappaB activity and increased IL-10 in TCR-triggered thymocytes of transgenic mice overexpressing the glucocorticoid-induced protein GILZ.
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NK cells in autoimmune diseases: Linking innate and adaptive immune responses.
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Association of inflammatory mediators with pain perception.
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Survival of a neglected case of brain abscess caused by Cladophialophora bantiana.
TLDR
A case of a patient who survived a recurrent cerebral abscess caused by C. bantiana despite delayed and apparently inappropriate therapy is reported.
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Cloning and expression of a short Fas ligand: A new alternatively spliced product of the mouse Fas ligand gene.
TLDR
RNase protection and immunoprecipitation analysis showed that FasLs is expressed in nonactivated normal spleen cells and in hybridoma T cells and that it is upregulated upon activation by anti-CD3 monoclonal antibody (MoAb).
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Interleukin-6 (IL-6) prevents activation-induced cell death: IL-2-independent inhibition of Fas/fasL expression and cell death.
TLDR
The results indicated that transcription of Fas/FasL is controlled by interleukin-2 (IL-2) production and that CD2 triggering rescues a T-cell hybridoma from AICD via decreased production of IL-2, indicating that, in contrast to CD2, IL-6 inhibits apoptosis but not IL- 2-induced activation.
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