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In Vivo Detection of Human TRPV6-Rich Tumors with Anti-Cancer Peptides Derived from Soricidin
Molecular imaging methods that demonstrate the in vivo diagnostic potential of S OR-C13 and SOR-C27 to target tumor sites in mice bearing ovarian or prostate tumors suggest that these novel peptides may provide an avenue to deliver diagnostic and therapeutic reagents directly to TRPV6-rich tumors. Expand
Clearance of depot vaccine SPIO-labeled antigen and substrate visualized using MRI.
MRI results indicate that MRI can visualize the in vivo longitudinal biodistribution of vaccine components, which corresponds to the sustained immune responses and reduced tumor burden observed in vaccinated mice. Expand
Butyrylcholinesterase-knockout reduces fibrillar β-amyloid and conserves 18FDG retention in 5XFAD mouse model of Alzheimer’s disease
In knocking out BChE and reducing fibrillar Aβ, a possible protective effect on brain function may be conferred in a number of structures in 5XFAD/BChE-KO mice. Expand
Spatial MEG Laterality maps for language: Clinical applications in epilepsy
It is argued that the laterality concept is better presented with the inherent spatial sensitivity of activation maps, rather than being collapsed into a one‐dimensional index. Expand
Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer’s Disease
The predictive value of BChE as a biomarker for AD that could facilitate timely disease diagnosis and management is highlighted and is compared to Aβ, thioflavin-S, and BE quantification of 26 postmortem brain tissues. Expand
Early Detection of Cerebral Glucose Uptake Changes in the 5XFAD Mouse
It is concluded that brain 18 FDG uptake can be a sensitive biomarker for early detection of abnormal metabolism in the 5XFAD mouse when alternative relative uptake values are utilized. Expand
Using lymph node swelling as a potential biomarker for successful vaccination
There is currently a lack of biomarkers to help properly assess novel immunotherapies at both the preclinical and clinical stages of development. Recent work done by our group indicated significantExpand
Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease
Butyrylcholinesterase (BChE), which becomes associated with these structures in AD, could elevate the accuracy of AD diagnosis by focusing on B ChE pathology in the cerebral cortex, a region of scant BChE activity in healthy brain. Expand
Using MRI to evaluate and predict therapeutic success from depot-based cancer vaccines
For this tumor model, early MRI lymph node volumetric changes are predictive of depot immunotherapeutic success, indicating high specificity and sensitivity as a predictive biomarker of vaccine efficacy. Expand