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Biofilms as complex differentiated communities.
It is submitted that complex cell-cell interactions within prokaryotic communities are an ancient characteristic, the development of which was facilitated by the localization of cells at surfaces, which may have provided the protective niche in which attached cells could create a localized homeostatic environment. Expand
Pseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm
The results demonstrate that P. aeruginosa displays multiple phenotypes during biofilm development and that knowledge of stage-specific physiology may be important in detecting and controlling biofilm growth. Expand
Understanding biofilm resistance to antibacterial agents
  • D. Davies
  • Biology, Medicine
  • Nature Reviews Drug Discovery
  • 1 February 2003
The mechanisms that underlie biofilm resistance to antimicrobial chemotherapy will be examined, with particular attention being given to potential avenues for the effective treatment of biofilms. Expand
A Fatty Acid Messenger Is Responsible for Inducing Dispersion in Microbial Biofilms
It is demonstrated that, during growth, Pseudomonas aeruginosa produces an organic compound, identified as cis-2-decenoic acid, which is capable of inducing the dispersion of established biofilms and of inhibiting biofilm development. Expand
Characterization of Nutrient-Induced Dispersion in Pseudomonas aeruginosa PAO1 Biofilm
It is demonstrated here that dispersal of Pseudomonas aeruginosa PAO1 from biofilms is inducible by a sudden increase in carbon substrate availability and changes in gene expression associated with dispersion of P. aerug inosa correlates with a specific dispersal phenotype. Expand
Characterization of Temporal Protein Production in Pseudomonas aeruginosa Biofilms
The results indicated that expression of theses genes was required for the progression of biofilms into three-dimensional structures on abiotic surfaces and the completion of the biofilm developmental cycle. Expand
The Putative Enoyl-Coenzyme A Hydratase DspI Is Required for Production of the Pseudomonas aeruginosa Biofilm Dispersion Autoinducer cis-2-Decenoic Acid
A putative enoyl-coenzyme A (CoA) hydratase/isomerase that is required for synthesis of the biofilm dispersion autoinducer cis-2-decenoic acid in the human pathogen Pseudomonas aeruginosa is identified. Expand
Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa.
The conservation of PPK among many bacterial pathogens and its absence in eukaryotes suggest that PPK might be an attractive target for antimicrobial drugs. Expand
Exopolysaccharide production in biofilms: substratum activation of alginate gene expression by Pseudomonas aeruginosa
Reporter gene technology was employed to detect the activity of an alginate promoter of Pseudomonas aeruginosa when the organism was grown as a biofilm on a Teflon mesh substratum and as planktonicExpand
Biofilms and Biocomplexity
This work states that biofilms are implicated in more than 80% of chronic inflammatory and infectious diseases caused by bacteria, including otitis media, endocarditis, gastrointestinal ulcers, infections of the urinary tract, and pulmonary infections in cystic fibrosis patients. Expand