D. Dartt

Publications334
h-index49
Citations6,891
Highly Influential Citations205
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Neural regulation of lacrimal gland secretory processes: Relevance in dry eye diseases
  • D. Dartt
  • Biology, Medicine
  • Progress in Retinal and Eye Research
  • 1 May 2009
The lacrimal gland is the major contributor to the aqueous layer of the tear film which consists of water, electrolytes and proteins. The amount and composition of this layer is critical for the… Expand
  • 260
  • 14
TFOS DEWS II pain and sensation report.
Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect wetness and reflexly… Expand
  • 166
  • 11
  • PDF
Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes.
PURPOSE To compare the bacterial population of the ocular surface of normal and dry eye subjects using conventional culture and 16S rDNA PCR. METHODS Ninety-one subjects were classified as normal… Expand
  • 140
  • 9
Signal transduction and control of lacrimal gland protein secretion: a review.
  • D. Dartt
  • Biology, Medicine
  • Current eye research
  • 1 June 1989
Proteins in lacrimal gland fluid are secreted primarily by the acinar cells. Secretory proteins are synthesized in the endoplasmic reticulum, modified in the Golgi apparatus, stored in secretory… Expand
  • 141
  • 7
Regulation of mucin and fluid secretion by conjunctival epithelial cells
  • D. Dartt
  • Biology, Medicine
  • Progress in Retinal and Eye Research
  • 1 November 2002
Tears play a vital role in the health and protection of the cornea and conjunctiva. The tear film consists of multiple layers and different glands secrete each layer. Because of many and varied… Expand
  • 132
  • 6
Dry eye after refractive surgery
Photorefractive keratectomy and laser in situ keratomileusis can induce or exacerbate dry eye after surgery. This manifests as an increase in degree and frequency of symptoms, corneal findings, such… Expand
  • 135
  • 6
Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva.
An epithelial debridement wound, as a stimulus to the cornea, causes conjunctival goblet cell mucous secretion in that eye. To determine if this stimulation of secretion is neurally mediated, rats… Expand
  • 77
  • 5
Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes.
The intestinal brush border (BB) Na+/H+ exchanger isoform 3 (NHE3) is acutely inhibited by elevation in the concentration of free intracellular Ca2+ ([Ca2+]i) by the cholinergic agonist carbachol and… Expand
  • 90
  • 5
  • PDF
Lacrimal gland electrolyte and water secretion in the rabbit: localization and role of (Na+ + K+)‐activated ATPase.
1. The rate of acetylcholine (ACh)‐induced fluid secretion was measured from the main secretory duct of rabbit lacrimal glands perfused in vivo with Krebs Henseleit bicarbonate solutions. 2.… Expand
  • 66
  • 5
Characterization of P2X7 purinergic receptors and their function in rat lacrimal gland.
PURPOSE To characterize the effects of P2X(7) purinergic receptors on lacrimal gland function. METHODS P2X(7) purinergic receptors were identified by RT-PCR, Western blot analysis, and… Expand
  • 26
  • 5
  • PDF