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IDH1 and IDH2 mutations in gliomas.
BACKGROUND A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in aExpand
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Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
BACKGROUND Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior thatExpand
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Glioblastoma multiforme: a review of where we have been and where we are going
Malignant gliomas such as glioblastoma multiforme (GBM) present some of the greatest challenges in the management of cancer patients worldwide, despite notable recent achievements in oncology. EvenExpand
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Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. AsExpand
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Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
Glioblastomas shed large quantities of small, membrane-bound microvesicles into the circulation. Although these hold promise as potential biomarkers of therapeutic response, their identification andExpand
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Proteomic and immunologic analyses of brain tumor exosomes
Brain tumors are horrific diseases with almost universally fatal outcomes; new therapeutics are desperately needed and will come from improved understandings of glioma biology. Exosomes are endo‐Expand
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Recurrent Glioblastoma Treated with Recombinant Poliovirus
BACKGROUND The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently no effective therapy. We conducted a dose‐finding andExpand
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A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.
Monoallelic point mutations of the NADP(+)-dependent isocitrate dehydrogenases IDH1 and IDH2 occur frequently in gliomas, acute myeloid leukemias, and chondromas, and display robust association withExpand
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Medical Diagnostic Radiation Exposures and Risk of Gliomas
Abstract High-dose ionizing radiation is an established risk factor for glioma, but it remains unknown whether moderate- and low-dose radiation increase glioma risk. In this analysis, we assessed theExpand
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EGFRvIII‐Targeted Vaccination Therapy of Malignant Glioma
Given the highly infiltrative growth pattern of malignant glioma and the lack of specificity associated with currently available treatment regimens, alternative strategies designed to eradicateExpand
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