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The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis
TLDR
It is indicated that Δ-9-THC produces a broad range of transient symptoms, behaviors, and cognitive deficits in healthy individuals that resemble some aspects of endogenous psychoses and warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders.
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
TLDR
It is considered the possibility that agents that attenuate these two components of NMDA receptor antagonist response may play complementary roles in the treatment of schizophrenia.
Spicing things up: synthetic cannabinoids
TLDR
There is an urgent need for better research on the effects of synthetic cannabinoids to help clinicians manage adverse events and to better understand cannabinoid pharmacology in humans.
The acute effects of cannabinoids on memory in humans: a review
TLDR
This profile of effects suggests that cannabinoids impair all stages of memory including encoding, consolidation, and retrieval, and that cannabinoids increase intrusion errors with the inhaled and intravenous route and correspond to peak drug levels.
Cannabis and psychosis/schizophrenia: human studies
TLDR
Converting lines of evidence suggest that cannabinoids can produce a full range of transient schizophrenia-like positive, negative, and cognitive symptoms in some healthy individuals, and novel hypotheses including the role of cannabinoids on neurodevelopmental processes relevant to psychotic disorders are being studied.
Gone to Pot – A Review of the Association between Cannabis and Psychosis
TLDR
The evidence indicates that cannabis may be a component cause in the emergence of psychosis, and this warrants serious consideration from the point of view of public health policy.
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