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The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis
It is indicated that Δ-9-THC produces a broad range of transient symptoms, behaviors, and cognitive deficits in healthy individuals that resemble some aspects of endogenous psychoses and warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders.
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
- J. Krystal, D. D’Souza, D. Mathalon, E. Perry, A. Belger, R. Hoffman
- Psychology, MedicinePsychopharmacology
- 2 September 2003
It is considered the possibility that agents that attenuate these two components of NMDA receptor antagonist response may play complementary roles in the treatment of schizophrenia.
Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction
Spicing things up: synthetic cannabinoids
There is an urgent need for better research on the effects of synthetic cannabinoids to help clinicians manage adverse events and to better understand cannabinoid pharmacology in humans.
The acute effects of cannabinoids on memory in humans: a review
This profile of effects suggests that cannabinoids impair all stages of memory including encoding, consolidation, and retrieval, and that cannabinoids increase intrusion errors with the inhaled and intravenous route and correspond to peak drug levels.
Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions
Dose-Related Behavioral, Subjective, Endocrine, and Psychophysiological Effects of the κ Opioid Agonist Salvinorin A in Humans
Nicotine effects on brain function and functional connectivity in schizophrenia
Cannabis and psychosis/schizophrenia: human studies
- D. D’Souza, R. A. Sewell, M. Ranganathan
- Psychology, MedicineEuropean Archives of Psychiatry and Clinical…
- 16 July 2009
Converting lines of evidence suggest that cannabinoids can produce a full range of transient schizophrenia-like positive, negative, and cognitive symptoms in some healthy individuals, and novel hypotheses including the role of cannabinoids on neurodevelopmental processes relevant to psychotic disorders are being studied.
Gone to Pot – A Review of the Association between Cannabis and Psychosis
The evidence indicates that cannabis may be a component cause in the emergence of psychosis, and this warrants serious consideration from the point of view of public health policy.