• Publications
  • Influence
Coronary artery stretch versus deep injury in the development of in-stent neointima
Objective: To investigate the relative importance of stent induced arterial stretch and deep injury to the development of in-stent neointima. Setting: Normal porcine coronary arteries Methods: 30Expand
  • 109
  • 10
  • PDF
Brain inflammation is induced by co-morbidities and risk factors for stroke
Highlights ► Risk factors for stroke include atherosclerosis, obesity, diabetes and hypertension. ► Stroke risk factors are associated with peripheral inflammation. ► Corpulent rats and atherogenicExpand
  • 162
  • 8
  • PDF
GATA2 Is Associated with Familial Early-Onset Coronary Artery Disease
The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up theExpand
  • 95
  • 5
Transforming growth factor-β1 gene polymorphisms and coronary artery disease
1. A meta-analysis of 17 years of literature on erythrocyte Na+/Li+ countertransport (NLCT) and Na+/K+ co-transport (COT) measurements in relation to essential hypertension is presented. The analysisExpand
  • 122
  • 4
  • PDF
A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study.
A family history of coronary artery disease (CAD), especially when the disease occurs at a young age, is a potent risk factor for CAD. DNA collection in families in which two or more siblings areExpand
  • 175
  • 4
Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-upExpand
  • 88
  • 3
Modeling cardiovascular disease in the zebrafish.
The zebrafish possesses a host of advantages that have established it as an excellent model of vertebrate development. These include ease of genetic manipulation and transgenesis, optical clarity,Expand
  • 108
  • 2
Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study)
BackgroundAcute Coronary Syndromes account for 15% of deaths in the UK, and patients remain at significant risk of re-admission for future complications and death. Pathologically the underlyingExpand
  • 70
  • 2
  • PDF
Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study.
BACKGROUND Coronary artery disease (CAD) is the leading cause of death and a leading cause of disability in the developed world. Early onset (premature) coronary artery disease (EOCAD) is known toExpand
  • 65
  • 2
The pathophysiology of myocardial ischaemia
Myocardial ischaemia is responsible for angina, unstable angina, and, less commonly, shortness of breath secondary to ischaemic left ventricular dysfunction (angina equivalent) as well as cardiacExpand
  • 50
  • 2
  • PDF