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Subgrid-Scale Parameterization with Conditional Markov Chains
TLDR
A new approach for stochastic parameterization of subgrid-scale processes in models of atmospheric flow has drawn a lot of research attention recently. Expand
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Structure-Immunogenicity Relationships of Therapeutic Proteins
As more recombinant human proteins become available on the market, the incidence of immunogenicity problems is rising. The antibodies formed against a therapeutic protein can result in seriousExpand
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Liposomal and Lipid Formulations of Amphotericin B
SummaryAmphotericin B remains a very important drug for the treatment of fungal infections despite its toxicity. Encapsulation of amphotericin B into liposomes appears to reduce the toxic effects andExpand
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Liposomes: quo vadis?
Abstract Liposomes have matured as a delivery system for therapeutic agents. It has taken two decades to develop the liposome carrier concept to a pharmaceutical product level, but commercialExpand
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The effect of a water/organic solvent interface on the structural stability of lysozyme.
The effect of emulsification of lysozyme solutions with methylene chloride on protein recovery and structural integrity was investigated. Total lysozyme recovery in the aqueous phase was found to beExpand
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Lymphatic uptake and biodistribution of liposomes after subcutaneous injection. II. Influence of liposomal size, lipid compostion and lipid dose.
The present paper reports on the results of a systematic study on liposome variables potentially affecting lymphatic disposition and biodistribution of liposomes after sc injection. Liposomal sizeExpand
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Identification of Formaldehyde-induced Modifications in Proteins
Formaldehyde is a well known cross-linking agent that can inactivate, stabilize, or immobilize proteins. The purpose of this study was to map the chemical modifications occurring on each naturalExpand
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A Hidden Markov Model Perspective on Regimes and Metastability in Atmospheric Flows
TLDR
In this study, data from three atmospheric models are analyzed to investigate the existence of atmospheric flow regimes despite nearly Gaussian statistics of the planetary waves in these models. Expand
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Effect of Size and Serum Proteins on Transfection Efficiency of Poly ((2-dimethylamino)ethyl Methacrylate)-Plasmid Nanoparticles
AbstractPurpose. The aim of this study was to gain insight into the relation between the physical characteristics of particles formed by a plasmid and a synthetic cationic polymerExpand
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On the structure of immune-stimulating saponin-lipid complexes (iscoms).
Immune-stimulating complexes (iscoms) are stable complexes of cholesterol, phospholipid and Quil A, a triterpene saponin mixture in the size range from 40 to 100 nm. They can be used as antigenExpand
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