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The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus.
TLDR
The aim of this study was to review the role of UCP1 in the development of these metabolic diseases and to identify genes associated with DM2 and/or obesity.
Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus
TLDR
This work investigated whether the −866G/A, Ala55Val and 45 bp insertion/deletion (Ins/Del) polymorphisms in the UCP2 gene might be associated with proliferative DR (PDR).
Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis.
TLDR
The results indicate that in a case-control study, the homozygosity for D2 Thr92Ala polymorphism is associated with increased risk for DM2, and support a role for intracellular T(3) concentration in skeletal muscle on DM2 pathogenesis.
MicroRNA expression profiles and type 1 diabetes mellitus: systematic review and bioinformatic analysis
TLDR
Eleven circulating miRNAs seem to be dysregulated in T1DM patients in different studies, being potential circulating biomarkers of this disease.
The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications.
TLDR
Uncoupling protein 2 (UCP2) is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism, which are associated with DM2 pathogenesis and its chronic complications.
Associations between UCP1 -3826A/G, UCP2 -866G/A, Ala55Val and Ins/Del, and UCP3 -55C/T Polymorphisms and Susceptibility to Type 2 Diabetes Mellitus: Case-Control Study and Meta-Analysis
TLDR
A case-control study and a meta-analysis were conducted to determine whether the following polymorphisms are associated with type 2 diabetes mellitus and were not able to demonstrate any association; however, a significant association was detected between the UCP2 Ala55Val and UCP3 -55C/T polymorphisms and increased susceptibility for T2DM in Asians.
Meta-Analysis Reveals the Association of Common Variants in the Uncoupling Protein (UCP) 1–3 Genes with Body Mass Index Variability
TLDR
A meta-analysis detected a significant association between the UCP2-866G/A, Ins/Del, Ala55Val and UCP3-55C/T polymorphisms and BMI mean differences.
Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.
TLDR
It is suggested that cytokine-induced NF-kappaB activation in insulin-producing cells is more rapid, marked, and sustained than in fibroblasts, which correlates with a more pronounced activation of downstream genes and a proapoptotic outcome.
Polymorphisms in the TLR3 gene are associated with risk for type 1 diabetes mellitus.
TLDR
The number of risk alleles of the five TLR3 polymorphisms in the haplotypes seems to influence the risk for T1DM, suggesting that these polymorphisms might interact in the susceptibility for the disease.
The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil.
TLDR
The results confirm the association between the TCF7L2 rs7903146 polymorphism and increase risk for type 2 diabetes in Southern-Brazil.
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