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Integrated Genomic Analyses of Ovarian Carcinoma
It is reported that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1,BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Expand
The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome
- F. Medeiros, M. Muto, +6 authors C. Crum
- Biology, Medicine
- The American journal of surgical pathology
- 1 February 2006
The fimbria was the most common location for early serous carcinoma in this series of BRCA-positive women, and Investigative strategies targeting the fimbriated end of the fallopian tube should further define its role in the pathogenesis of familial and sporadic ovarianSerous carcinomas. Expand
Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies
Clinicians should be aware of the increased risk of specific subtypes of ovarian cancer in women with endometriosis, and future efforts should focus on understanding the mechanisms that might lead to malignant transformation of endometRIosis so as to help identify subsets of women at increased riskof ovarian cancer. Expand
Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies.
Data suggest a role for specific biologic causes of infertility, but not for fertility drugs in overall risk for ovarian cancer, as suggested in case-control studies conducted between 1989 and 1999. Expand
Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis.
Entrapment of surface epithelium within the ovarian stroma was proposed as an initial event in the pathogenesis of cystadenocarcinoma of the ovary and animal experiments suggested that gonadotropin excess and stromal stimulation may result by disturbing normal feedback inhibition between ovarian and pituitary or by destroying ovarian follicles. Expand
Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology.
- S. Mok, J. Chao, +5 authors D. Cramer
- Biology, Medicine
- Journal of the National Cancer Institute
- 3 October 2001
Prostasin is overexpressed in epithelial ovarian cancer and should be investigated further as a screening or tumor marker, alone and in combination with CA 125. Expand
Population based study of coffee, alcohol and tobacco use and risk of ovarian cancer
- H. Kuper, L. Titus-Ernstoff, B. Harlow, D. Cramer
- International journal of cancer
- 15 October 2000
It is concluded that coffee and caffeine consumption may increase risk for ovarian cancer among premenopausal women and are findings that have some epidemiologic and biologic support. Expand
Osteopontin as a potential diagnostic biomarker for ovarian cancer.
The findings provide evidence for an association between levels of a biomarker, osteopontin, and ovarian cancer and suggest that future research assessing its clinical usefulness would be worthwhile. Expand
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Using the Illumina custom genotyping array iCOGs, SNPs at the TERT locus in breast, ovarian and BRCA1 mutation carrier cancer cases and controls and leukocyte telomere measurements are analyzed to find associations cluster into three independent peaks. Expand