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The mechanisms of drug release from solid dispersions in water-soluble polymers.
  • D. Craig
  • Chemistry, Medicine
  • International journal of pharmaceutics
  • 14 January 2002
A model is proposed whereby the release behaviour from the dispersions may be understood in terms of the dissolution or otherwise of the drug into the concentrated aqueous polymer layer adjacent to the solid surface, including a derivation of an expression to describe the release of intact particles from the dispersed particles. Expand
The relevance of the amorphous state to pharmaceutical dosage forms: glassy drugs and freeze dried systems.
The nature of the glassy state will be described, with particular emphasis on the molecular processes associated with glass transitional behaviour and the use of thermal methods for characterising the glass transition temperature, Tg. Expand
A comparison of different in vitro methods for measuring mucoadhesive performance
Abstract The purpose of this study was to assess and compare several in vitro methods for measuring mucoadhesive performance, using a controlled-stress rheometer and a penetrometer (textureExpand
An Evaluation of the Mechanisms of Drug Release from Glyceride Bases
A series of dispersions containing theophylline in Gelucires 43/01, 54/02, 50/02, 50/13 and 55/18 was prepared and the physical structures studied using differential scanning calorimetry. TheExpand
Achieving Antral Grinding Forces in Biorelevant In Vitro Models: Comparing the USP Dissolution Apparatus II and the Dynamic Gastric Model with Human In Vivo Data
The grinding forces of a recently developed computer-controlled, real-time physical simulator of gastric processing, the Dynamic Gastric Model (DGM) and a Dissolution Apparatus USP-II, operated at two rotational speeds, were measured using the breakdown of agar gel beads of various fracture strengths in high- and low-viscosity meals. Expand
A review of thermal methods used for the analysis of the crystal form, solution thermodynamics and glass transition behaviour of polyethylene glycols
Abstract The uses, properties and structure of polyethylene glycols are discussed, with particular emphasis on pharmaceutical considerations. The applications of thermal techniques in theExpand
Thermal Analysis Of Pharmaceuticals
As a result of the Process Analytical Technologies (PAT) initiative launched by the U.S. Food and Drug Administration (FDA), analytical development is receiving more attention within theExpand
Influence of process parameters on fluidised hot-melt granulation and tablet pressing of pharmaceutical powders
This study investigates the influence of process parameters on the fluidised hot melt granulation of lactose and PEG 6000, and the subsequent tablet pressing of the granules. Granulation experimentsExpand
An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy
Abstract A series of mixtures comprising Imwitor 742 and Tween 80 have been prepared and their self-emulsifying properties studied using a method of visual examination. The particle sizeExpand
Influence of silicone elastomer solubility and diffusivity on the in vitro release of drugs from intravaginal rings.
Given that the silicone solubility and silicone diffusion coefficient are the major parameters influencing the permeation of drugs through silicone elastomers, it is now possible to predict through use of the appropriate mathematical equations both matrix-type and reservoir-type intravaginal ring release rates simply from a knowledge of drug melting temperature and molecular weight. Expand