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Primary linitis plastica of the rectum
TLDR
One case of primary linitis plastica of the rectum is presented and Pathologically, this tumor is characterized by diffuse infiltration of the bowel wall by cells of the signet ring type. Expand
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
TLDR
Whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis is investigated. Expand
The association between Hirschsprung’s disease and multiple endocrine neoplasia type 2a: a systematic review
TLDR
While the overall incidence of HSCR co-occurring with MEN2A is low, both conditions occur with a relatively high frequency in families with a RET mutation at exon 10, re-inforce the importance of RET mutation testing in H SCR when a family history of either HSCr or MEN2 is present. Expand
Hirschsprung’s disease in children with Mowat–Wilson syndrome
TLDR
The data suggest an increased prevalence of long-segment aganglionosis and an increased risk of clinically significant persistent bowel symptoms following pull-through surgery, in many cases necessitating terminal stoma formation. Expand
Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease.
TLDR
Investigation of SK3 channel expression in ganglionic bowel found decreased SK3 expression may explain the basis of persistent bowel symptoms in some patients following a properly performed pull-through operation for HSCR. Expand
Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung’s disease
TLDR
Abnormal distribution of ANO1-positive ICCs in the ganglionic colon in HSCR may contribute to persistent bowel symptoms in some patients after pull-through surgery. Expand
Gonadoblastoma in patients with 45,X/46,XY mosaicism: A 16-year experience.
TLDR
It is recommended that all patients with intra-abdominal gonads in the context of TMSY should duly undergo prophylactic gonadectomy, although the timing of such surgery can be discussed with parents during counselling regarding the risk of malignancy. Expand
Deficiency of platelet-derived growth factor receptor-α-positive cells in Hirschsprung's disease colon.
TLDR
Findings suggest that the altered distribution of PDGFRα(+)-cells in both the aganglionic and ganglionic HD bowel may contribute to the motility dysfunction in HD. Expand
Altered neurotransmitter expression profile in the ganglionic bowel in Hirschsprung's disease.
TLDR
Imbalance of key excitatory and inhibitory neurotransmitters in the ganglionic bowel in HSCR may explain the basis of bowel dysmotility after an optimal pull-through operation in some patients. Expand
Altered expression of a two-pore domain (K2P) mechano-gated potassium channel TREK-1 in Hirschsprung’s disease
TLDR
The decreased TREK-1 expression in the aganglionic and ganglionic bowel observed in HSCR may alter intestinal epithelial barrier function leading to the development of enterocolitis. Expand
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