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TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction
The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein
The DYT1 gene on human chromosome 9q34 is identified as being responsible for early-onset torsion dystonia, a movement disorder, characterized by twisting muscle contractures, that begins in childhood.
Lighting up the Senses: FM1-43 Loading of Sensory Cells through Nonselective Ion Channels
A novel mechanism for vital fluorescent dye entry into sensory cells and neurons: permeation through ion channels is described, suggesting that organic cationic dyes are able to pass through a number of different sensory channels.
Unconventional Myosins in Inner-Ear Sensory Epithelia
This work examined the distribution of four unconventional myosin isozymes in the inner ear, a tissue that is particularly reliant on actin-rich structures and unconventionalMyosin wasozymes, and localization results suggest specific functions for three hair-cell myosins.
Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning
A reinterpretation of mammalian sodium channel gating based on single channel recording
Some of the traditionally held views about how sodium channels work are shown to be incorrect and a new approach to physical theories of sodium channel operation is suggested.
Tip-link integrity and mechanical transduction in vertebrate hair cells
Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B.
- T. Hasson, M. Heintzelman, J. Santos-Sacchi, D. Corey, M. Mooseker
- BiologyProceedings of the National Academy of Sciences…
- 10 October 1995
The cell-specific localization of myosin VIIa suggests that the blindness and deafness associated with Usher syndrome is due to lack of proper myosIn VIIa function within the cochlear hair cells and the retinal pigmented epithelial cells.
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
Inhibition of TRPA1 protein expression in zebrafish and mouse inner ears inhibits receptor cell function, as assessed with electrical recording and with accumulation of a channel-permeant fluorescent dye.
Kinetics of the receptor current in bullfrog saccular hair cells
The dependences of the response kinetics on displacement and on temperature suggest that the thermal interconversion between open and closed transduction channels is limited by an enthalpy of activation of about 12 kcal/mol.