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Repression at a distance by the global regulator KorB of promiscuous IncP plasmids
TLDR
KorB protein binds to 12 highly conserved sequences on the RK2 genome and co‐ordinates the expression of at least five operons encoding genes for stable inheritance and plasmid transfer and gel retardation analysis showed that KorB binding is promoted by sequences upstream and downstream of OB9 and that Korb can form higher order complexes on DNA. Expand
Protease composition of exocytosed human skin mast cell protease-proteoglycan complexes. Tryptase resides in a complex distinct from chymase and carboxypeptidase.
TLDR
It is suggested that tryptase and carboxypeptidase/chymase reside in distinct macromolecular complexes, and separate complexes containing these proteases may help explain previous ultrastructural observations in which the distributions of chymase andtryptase within a single granule did not always coincide. Expand
Studies on the mode of action of coumarins (coumarin, 6-hydroxycoumarin, 7-hydroxycoumarin & esculetin) at a cellular level
Coumarin, a member of the benzopyrone family of compounds, is a natural substance that has shown anti-tumour activity in vivo, with this effect believed to be due to its metabolites. However, no Expand
Comparison of the tetrazolium salt assay for succinate dehydrogenase with the cytosensor microphysiometer in the assessment of compound toxicities.
TLDR
The cytosensor microphysiometer (a biosensing instrument for detecting cellular metabolism) was compared to the established tetrazolium salt assay as a chemosensitivity test and proved to be superior to the tetrazolate salt assay for a number of reasons. Expand
Role of residue Lys315 in the mechanism of action of the Enterobacter cloacae 908R beta-lactamase.
TLDR
The role of the highly conserved Lys315 residue in the catalytic mechanism of a class C beta-lactamase has been probed by site-directed mutagenesis and it was suggested that Lys315 was somehow involved in accelerating the nucleophilic substitutions along the reaction pathway. Expand
Studies on the cytostatic and cytotoxic effects and mode of action of 8-nitro-7-hydroxycoumarin.
TLDR
A derivative of coumarin, 8-nitro- 7-hydroxycoumarin (8-NO2-7-OHC), was synthesised, purified and characterised and was shown to be non-mutagenic in a standard Ames test, both with or without a mammalian enzyme activation system. Expand
Clostridium difficile toxin A binding to human intestinal epithelial cells.
TLDR
The reduction of [3H]-toxin A binding, after the removal of beta-linked galactose units, implicates these as components of the receptor and adds credence to the idea that the Lewis X, Y and I antigens may be involved in toxin A binding to human intestinal epithelial cells. Expand
Keto/enol epoxy steroids as HIV-1 Tat inhibitors: structure-activity relationships and pharmacophore localization.
TLDR
There is a weak enantioselective preference for the natural steroid stereochemistry and hints of additional SAR in the electron-withdrawing group for the steroid series and the localization of the pharmacophore to the A-ring functionality. Expand
Interactions of immunoglobulins and chondrocytes.
TLDR
Heat aggregation of the IgG enhanced its effect on O2- and S-GAG and similar responses of chondrocytes in vivo might account for immune complex mediated damaged cartilage. Expand
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