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Vascular permeability factor, an endothelial cell mitogen related to PDGF.
TLDR
The cDNA sequence of VPF from human U937 cells was shown to code for a 189-amino acid polypeptide that is similar in structure to the B chain of platelet-derived growth factor (PD GF-B) and other PDGF-B-related proteins, suggesting that VPF appears to be related to the PDGF/v-sis family of proteins.
Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.
TLDR
125I-VPF was shown to bind specifically and with high affinity to endothelial cells in vitro and could be chemically cross-linked to a high-molecular weight cell surface receptor, thus demonstrating a mechanism whereby VPF can interact directly with endothelial Cells.
(d)-β-Hydroxybutyrate Inhibits Adipocyte Lipolysis via the Nicotinic Acid Receptor PUMA-G*
TLDR
It is shown that the fatty acid-derived ketone body (d)-β-hydroxybutyrate ((d-β-OHB) specifically activates PUMA-G/HM74a at concentrations observed in serum during fasting, thereby preventing ketoacidosis and promoting efficient use of fat stores.
Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B.
TLDR
The diversity of both hit lists and their dissimilarity from each other suggest that docking and HTS may be complementary techniques for lead discovery.
Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
TLDR
Results indicate that VPF can modulate the coagulant properties of endothelium and monocytes, and can promote monocyte migration into the tumor bed, which suggests one mechanism through which tumor-derived mediators can alter properties of the vessel wall.
Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.
TLDR
Findings establish that this NH2-terminal amino acid sequence was derived from the permeability factor, indicating that VPF is distinct from other proteins for which sequence data are available.
Langerhans cells release prostaglandin D2 in response to nicotinic acid.
TLDR
Results suggest that nicotinic acid mediates its flushing side effect by interacting with GPR109A on skin Langerhans cells, resulting in release of PGD(2).
Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor.
TLDR
The expression pattern and signaling for GPR22 are described for the first time and a protective role is identified in response to hemodynamic stress resulting from increased afterload.
Human vascular permeability factor. Isolation from U937 cells.
TLDR
HVPF was purified from serum-free conditioned medium of the human histiocytic lymphoma cell line U937 as a disulfide-linked dimeric 40-kDa protein that promoted dermal blood vessel leakage in guinea pigs and promoted in vitro endothelial cell growth at concentrations as low as 50 PM.
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