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Fitting and Statistical Analysis of Single-Channel Records
The aims of analysis of single channel records can be considered in two categories: to allow one to observe results at leisure in order to determine their qualitative features and to allow highly automated methods of analysis to be fulfilled. Expand
A P2X purinoceptor expressed by a subset of sensory neurons
The remarkable selectivity of expression of the channel coupled with its sensory neuron-like pharmacology suggests that this channel may transduce ATP-evoked nociceptor activation. Expand
An investigation of the false discovery rate and the misinterpretation of p-values
  • D. Colquhoun
  • Computer Science, Medicine
  • Royal Society Open Science
  • 20 July 2014
It is concluded that if you wish to keep your false discovery rate below 5%, you need to use a three-sigma rule, or to insist on p≤0.001, and never use the word ‘significant’. Expand
Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate.
The fine structure of ion‐channel activations by junctional nicotinic receptors in adult frog muscle fibres has been investigated and the component of brief openings behaves, at low concentrations, as though it originates from openings of singly occupied channels. Expand
Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors
Four cloned subunits of the NMDA receptor have been expressed, in pairs, in Xenopus oocytes, and their single-channel properties have been measured, and the conductances of the channels turn out to be useful diagnostic criteria for subunit composition. Expand
The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms
Most mechanisms that are considered for ion channels (as for any other sort of chemical reaction) involve reversible transitions among the various possible discrete chemical states in which theExpand
On the stochastic properties of bursts of single ion channel openings and of clusters of bursts.
  • D. Colquhoun, A. Hawkes
  • Physics, Medicine
  • Philosophical transactions of the Royal Society…
  • 24 December 1982
These methods are generalized so that the observable characteristics of bursts can be calculated directly for any mechanism that has transition probabilities that are independent of time as long as the process is at equilibrium or is maintained in a steady state by an energy supply. Expand
Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices.
Double pulse application of glutamate indicated that even a 1 ms pulse of 1 mM glutamate causes partial desensitization of GluR channels, and the time course of recovery from desensItization was slower in dentate gyrus granule cell patches than in CA3 or CA1 pyramidal cell patches. Expand
Single‐channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors
It is shown that under certain conditions, the time constants for the macroscopic jump response should be the same as those for the distribution of super‐cluster lengths, though the resolution of the latter is so much greater that it cannot be expected that all the components will be resolvable in a Macroscopic current. Expand
ATP receptor-mediated synaptic currents in the central nervous system
The recording of evoked and miniature synaptic currents in the rat medial habenula showed that they were mediated by a ligand-activated ion channel rather than a second messenger system, thus limiting the known transmitter candidates. Expand