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Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999.
TLDR
This study presents a meta-analysis of the Methacholine Challenge Pretest Questionnaire results to assess the response of the participants and recommend further studies to investigate its application in clinical practice. Expand
Mechanisms of airway hyperresponsiveness.
TLDR
One component of AHR is transient or inducible and occurs after allergen exposure, for example, and improves occasionally rapidly after inhaled corticosteroids or environmental control; however, this transient airway hyperresponsiveness is more marked to the indirect stimuli. Expand
Possible protective effect against chronic obstructive airways disease by the GC2 allele.
TLDR
It is suggested that the GC 2 allele exerts a protective effect, whereas 1F, when homozygous, increases the risk of developing COAD. Expand
Direct challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance.
TLDR
In subjects with clinically current symptoms, a normal methacholine test rules out (current) asthma with reasonable certainty, and a positive test in the moderate or greater range (PC(20) < 1 mg/mL) has high specificity and positive predictive value, comparable to the indirect challenges. Expand
Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial
TLDR
The allergen-induced LAR and associated increased responsiveness are now believed to be more important clinically than the EAR and the potential inadequacy of bronchodilators used alone in the treatment of both perennial and seasonal allergic asthma is stressed. Expand
Effects of an anti-TSLP antibody on allergen-induced asthmatic responses.
TLDR
Findings are consistent with a key role for TSLP in allergen-induced airway responses and persistent airway inflammation in patients with allergic asthma and whether anti-TSLP therapeutics will have clinical value cannot be determined from these data. Expand
Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma.
TLDR
IL-13 has a role in allergen-induced airway responses in humans and further study is required to determine whether anti- IL-13 monoclonal antibodies will be beneficial clinically. Expand
Allergen‐induced increase in non‐allergic bronchial reactivity
TLDR
It is concluded that allergens make asthma worse, partly through non‐allergic mechanisms, and that avoidance of allergens is important in reducing non‐ allergic bronchial hyper‐reactivity. Expand
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