D. Cochrane

Publications63
h-index22
Citations2,092
Highly Influential Citations37
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Critical role of mast cells in inflammatory diseases and the effect of acute stress
Mast cells are not only necessary for allergic reactions, but recent findings indicate that they are also involved in a variety of neuroinflammatory diseases, especially those worsened by stress. In… Expand
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Nitric Oxide Inhibits Metamorphosis in Larvae of Crepidula fornicata, the Slippershell Snail
This paper concerns the role of nitric oxide (NO) in controlling metamorphosis in the marine gastropod Crepidula fornicata. Metamorphosis was stimulated by the nitric oxide synthase (NOS) inhibitors… Expand
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Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels.
1. Neurotensin stimulated histamine release and granule extrusion when applied to isolated rat peritoneal mast cells. 2. This secretory response was prevented by the removal of calcium or energy and… Expand
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Calcium-induced extrusion of secretory granules (exocytosis) in mast cells exposed to 48-80 or the ionophores A-23187 and X-537A.
  • D. Cochrane, W. Douglas
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 February 1974
Isolated peritoneal mast cells from rats were observed, by phase contrast microscopy, to extrude secretory granules when exposed to 48/80 or the ionophores A-23187 and X-537A, which are known to… Expand
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Evidence for a neurotensin receptor in rat serosal mast cells
Abstract.Objective and Design: The ability of neurotensin (NT) at nmolar levels to stimulate exocytosis of the mast cell suggested that it could play a role in neuro-immune-endocrine interactions.… Expand
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Ca2+ channel blockers enhance neurotensin (NT) binding and inhibit NT-induced inositol phosphate formation in prostate cancer PC3 cells.
Neurotensin (NT) stimulates Ca2+ release and Ca2+ influx in many cells. Its contractile effects in smooth muscle are inhibited by removal of Ca2+ and by Ca2+ channel blockers (CCBs). To better… Expand
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Histamine release by exocytosis from rat mast cells on reduction of extracellular sodium: a secretory response inhibited by calcium, strontium, barium or magnesium.
1. Histamine release from peritoneal mast cells of the rat was stimulated when the cells were exposed for 10 min to sodium‐deficient media where all NaCl had been replaced by KC1, RbC1, glucose,… Expand
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Expression of proinflammatory genes during estrogen‐induced inflammation of the rat prostate
Exposure of male Wistar rats to estradiol‐17β (E2) in the presence or absence of dihydrotestosterone propionate (DHT) was previously shown to result in prostate inflammation. The present study… Expand
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Rapid degradation of neurotensin by stimulated rat mast cells
A RIA towards neurotensin (NT) using C-terminal- and N-terminal-specific antisera was used to study degradation of this tridecapeptide by isolated rat mast cells. Incubation of NT (10 microM) with… Expand
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Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C.
Pretreatment of isolated rat serosal mast cells with U-73122, an aminosteroid inhibitor of phospholipase C, inhibited histamine secretion in response to neurotensin (NT). This inhibition reached a… Expand
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