D. Cochran

Publications341
h-index97
Citations31,903
Highly Influential Citations806
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Enhanced Bone Apposition to a Chemically Modified SLA Titanium Surface
TLDR
It is concluded that the modSLA surface promoted enhanced bone apposition during early stages of bone regeneration, as compared with a standard SLA surface.
The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction.
TLDR
Much of the damage that occurs duringperiodontal tissue destruction may very well represent an overreaction of the host response to periodontal pathogens caused by excessive production of IL-1 and TNF.
Inflammation and bone loss in periodontal disease.
  • D. Cochran
  • Biology, Medicine
    Journal of periodontology
  • 1 August 2008
TLDR
It seems that the reduction of inflammation and attenuation of the host's immune reaction to the microbial plaque, eventually leading to a decreases in the ratio of RANKL/OPG and a decrease in associated bone loss, are the actual and desired outcomes of periodontal therapy.
Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
TLDR
Case definitions in day-to-day clinical practice and in epidemiological or disease-surveillance studies for peri-implant health, peri"-implant mucositis, and peri'simplantitis were introduced.
High surface energy enhances cell response to titanium substrate microstructure.
  • G. Zhao, Z. Schwartz, B. Boyan
  • Materials Science, Engineering
    Journal of biomedical materials research. Part A
  • 1 July 2005
TLDR
Osteoblasts grown on modified Ti surfaces exhibited a more differentiated phenotype characterized by increased alkaline phosphatase activity and osteocalcin and generated an osteogenic microenvironment through higher production of PGE2 and TGF-beta1 and 1alpha,25OH2D3 increased these effects in a manner that was synergistic with high surface energy.
Biologic Width around one- and two-piece titanium implants.
TLDR
Findings, as evaluated by nondecalcified histology under unloaded conditions in the canine mandible, suggest that the gingival margin (GM) is located more coronally and Biologic Width (BW) dimensions are more similar to natural teeth around one-piece nonsubmerged implants compared to either two- piece nonsubMERged or two-piece submerged implants.
Crestal bone changes around titanium implants. A histometric evaluation of unloaded non-submerged and submerged implants in the canine mandible.
TLDR
These findings, as evaluated by non-decalcified histology under unloaded conditions, demonstrate that crestal bone changes occur during the early phase of healing after implant placement, and are dependent on the surface characteristics of the implant and the presence/absence of an interface.
Persistent Acute Inflammation at the Implant-Abutment Interface
TLDR
The absence of an implant-abutment interface (microgap) at the bone crest was associated with reduced peri-implant inflammatory cell accumulation and minimal bone loss.
Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63).
TLDR
It is demonstrated that surface roughness alters osteoblast proliferation, differentiation, and matrix production in vitro and suggests that implant surfaceroughness may play a role in determining phenotypic expression of cells in vivo.
Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation.
TLDR
The data from this randomized, masked, placebo-controlled multicenter clinical study demonstrated that the novel combination of rhBMP-2 and a commonly utilized collagen sponge had a striking effect on de novo osseous formation for the placement of dental implants.
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