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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
TLDR
It is found that TDP-43 autoregulates its synthesis, in part by directly binding and enhancing splicing of an intron in the 3′ untranslated region of its own transcript, thereby triggering nonsense-mediated RNA degradation.
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
TLDR
Onset and progression of amyotrophic lateral sclerosis represent distinct disease phases defined by mutant action within different cell types to generate non–cell-autonomous killing of motor neurons; these findings validate therapies, including cell replacement, targeted to the non-neuronal cells.
Unraveling the mechanisms involved in motor neuron degeneration in ALS.
TLDR
Along with errors in the handling of synaptic glutamate and the potential excitotoxic response this provokes, model systems highlight the involvement of nonneuronal cells in disease progression and provide new therapeutic strategies.
From charcot to lou gehrig: deciphering selective motor neuron death in als
TLDR
Insights into abnormalities in two genes, together with errors in the handling of synaptic glutamate and the potential excitotoxic response that this alteration provokes, have provided leads for the development of new strategies to identify an as yet elusive remedy for this progressive, fatal disorder.
Propagation of centromeric chromatin requires exit from mitosis
TLDR
A new covalent fluorescent pulse-chase labeling approach using SNAP tagging has now been developed and is used to demonstrate that CENP-A bound to a mature centromere is quantitatively and equally partitioned to sister centromeres generated during S phase, thereby remaining stably associated through multiple cell divisions.
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