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The genome of a songbird
The zebra finch is an important model organism in several fields with unique relevance to human neuroscience. Like other songbirds, the zebra finch communicates through learned vocalizations, anExpand
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Song presentation induces gene expression in the songbird forebrain.
We investigated the participation of genomic regulatory events in the response of the songbird brain to a natural auditory stimulus of known physiological and behavioral relevance, birdsong. Using inExpand
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The Genomic Action Potential
  • D. Clayton
  • Psychology, Medicine
  • Neurobiology of Learning and Memory
  • 1 November 2000
Neurons compute in part by integrating, on a time scale of milliseconds, many synaptic inputs and generating a digital output-the "action potential" of classic electrophysiology. Recent discoveriesExpand
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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the songExpand
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Dosage compensation is less effective in birds than in mammals
Background In animals with heteromorphic sex chromosomes, dosage compensation of sex-chromosome genes is thought to be critical for species survival. Diverse molecular mechanisms have evolved toExpand
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Song-induced ZENK gene expression in auditory pathways of songbird brain and its relation to the song control system
  • C. Mello, D. Clayton
  • Psychology, Medicine
  • The Journal of neuroscience : the official…
  • 1 November 1994
The ZENK gene encodes a zinc-finger-containing transcriptional regulator and can be rapidly activated in songbird brain by presentation of birdsong (Mello et al., 1992). Here we map the areas of theExpand
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Functional identification of sensory mechanisms required for developmental song learning
A young male zebra finch (Taeniopygia guttata) learns to sing by copying the vocalizations of an older tutor in a process that parallels human speech acquisition. Brain pathways that control songExpand
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Response Modulation in the Zebra Finch Neostriatum: Relationship to Nuclear Gene Regulation
The sound of birdsong activates robust gene expression in the caudomedial neostriatum (NCM) of songbirds. To assess the function of this genomic response, we analyzed the temporal and quantitativeExpand
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The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
Synuclein proteins are produced, in vertebrates, by three genes. They share structural resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in enriched amounts atExpand
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Development of song responses in the zebra finch caudomedial neostriatum: role of genomic and electrophysiological activities.
Zebra finches first form demonstrable memories of specific songs between 25 and 35 days of age--several days after fledging from the nest. What accounts for the late onset of specific song memoryExpand
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