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Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes*
It is reported that α-synuclein binds to small unilamellarospholipid vesicles containing acidic phospholipids, but not to vesicular charges with a net neutral charge, consistent with a role in vesicle function at the presynaptic terminal.
The genome of a songbird
This work shows that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets and shows evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience.
Song presentation induces gene expression in the songbird forebrain.
Results suggest a role for genomic responses in neural processes linked to song pattern recognition, discrimination, or the formation of auditory associations in songbird brain response to birdsong.
The Genomic Action Potential
  • D. Clayton
  • Medicine, Psychology
    Neurobiology of Learning and Memory
  • 1 November 2000
Critical review of the large literature describing the "immediate early gene" response leads to an alternative model of IEG function in the brain, which sets the overall gain or efficiency of memory formation and directs it to circuits engaged by behaviorally significant contexts.
Dosage compensation is less effective in birds than in mammals
Birds represent an unprecedented case in which genes on one sex chromosome are expressed on average at constitutively higher levels in one sex compared with the other, suggesting that some genomes can do without effective sex-specific sex-chromosome dosage compensation mechanisms.
Response Modulation in the Zebra Finch Neostriatum: Relationship to Nuclear Gene Regulation
A model in which nuclear responses in NCM are modulated by pathways distinct from the primary auditory inputs to NCM is proposed, which implies an active role for the cell nucleus as an integrating agent in the physiological operation of neural circuits.
Functional identification of sensory mechanisms required for developmental song learning
The hypothesis that molecular signaling in a sensory brain area outside of the song system is required for developmental song learning is tested and transiently suppressed the extracellular signal–regulated kinase signaling pathway in a portion of the auditory forebrain specifically during tutor song exposure is tested.