TRP channels as cellular sensors
- D. Clapham
- 4 December 2003
TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory…
An introduction to TRP channels.
The aim of this review is to provide a basic framework for understanding the function of mammalian transient receptor potential (TRP) channels, particularly as they have been elucidated in…
The mitochondrial calcium uniporter is a highly selective ion channel
By patch-clamping the inner mitochondrial membrane, it is concluded that the properties of the current mediated by this novel channel are those of the MCU, enabling high Ca2+ selectivity despite relatively low cytoplasmic Ca 2+ concentrations.
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
It is shown that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm.
EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex
Sancak et al. complete the molecular characterization of the mitochondrial calcium uniporter (MCU), the multicomponent channel that allows concentration of calcium within the organelle, and identify a small protein termed “essential MCU regulator”—or EMRE—which was required for calcium transport activity of the fully assembled uniporters.
The trp ion channel family
Three subgroups comprise the TRP channel family; the best understood of these mediates responses to painful stimuli, and other proposed functions include repletion of intracellular calcium stores, receptor-mediated excitation and modulation of the cell cycle.
TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels
The results support a role for temperature-sensitive TRP channels in chemesthesis in oral and nasal epithelium and suggest that TRPV3 may be a molecular target of plant-derived skin sensitizers.
TRPV3 is a calcium-permeable temperature-sensitive cation channel
It is proposed that hTRPV3 is thermosensitive in the physiological range of temperatures between TRPM8 and TRPV1.
A sperm ion channel required for sperm motility and male fertility
A putative sperm cation channel, CatSper, whose amino-acid sequence most closely resembles a single, six-transmembrane-spanning repeat of the voltage-dependent Ca2+-channel four-repeat structure is described, located specifically in the principal piece of the sperm tail.