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TRP channels as cellular sensors
TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensoryExpand
An introduction to TRP channels.
The aim of this review is to provide a basic framework for understanding the function of mammalian transient receptor potential (TRP) channels, particularly as they have been elucidated inExpand
The mitochondrial calcium uniporter is a highly selective ion channel
By patch-clamping the inner mitochondrial membrane, it is concluded that the properties of the current mediated by this novel channel are those of the MCU, enabling high Ca2+ selectivity despite relatively low cytoplasmic Ca 2+ concentrations. Expand
The trp ion channel family
Three subgroups comprise the TRP channel family; the best understood of these mediates responses to painful stimuli, and other proposed functions include repletion of intracellular calcium stores, receptor-mediated excitation and modulation of the cell cycle. Expand
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
It is shown that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm. Expand
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels
The results support a role for temperature-sensitive TRP channels in chemesthesis in oral and nasal epithelium and suggest that TRPV3 may be a molecular target of plant-derived skin sensitizers. Expand
TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain
It is demonstrated here that TRPC1 and TRPC5 are subunits of a heteromeric neuronal channel, and proposed that many TRPC heteromers form diverse receptor-regulated nonselective cation channels in the mammalian brain. Expand
TRPV3 is a calcium-permeable temperature-sensitive cation channel
It is proposed that hTRPV3 is thermosensitive in the physiological range of temperatures between TRPM8 and TRPV1. Expand
EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex
Sancak et al. complete the molecular characterization of the mitochondrial calcium uniporter (MCU), the multicomponent channel that allows concentration of calcium within the organelle, and identify a small protein termed “essential MCU regulator”—or EMRE—which was required for calcium transport activity of the fully assembled uniporters. Expand
TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities
Cloned and characterized a protein kinase and ion channel, TRP-PLIK, and inactivation of the kinase activity by site-directed mutagenesis and the channel's dependence on intracellular adenosine triphosphate (ATP) demonstrated that the channel’s Kinase activity is essential for channel function. Expand