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Evaluation of Early and Late Effects into the Acute Spinal Cord Injury of an Injectable Functionalized Self-Assembling Scaffold
The complex physiopathological events occurring after spinal cord injury (SCI) make this devastating trauma still incurable. Self-assembling peptides (SAPs) are nanomaterials displaying some… Expand
Nanomaterials design and tests for neural tissue engineering.
- G. A. Saracino, D. Cigognini, D. Silva, A. Caprini, F. Gelain
- Computer Science, Medicine
- Chemical Society reviews
- 7 January 2013
Nanostructured scaffolds can be tailored at the molecular level and scaffold morphology may more closely resemble features of extracellular matrix components in terms of porosity, framing and biofunctionalities. Expand
New bioactive motifs and their use in functionalized self-assembling peptides for NSC differentiation and neural tissue engineering.
Developing functionalized biomaterials for enhancing transplanted cell engraftment in vivo and stimulating the regeneration of injured tissues requires a multi-disciplinary approach customized for… Expand
Embryonic stem cells promote motor recovery and affect inflammatory cell infiltration in spinal cord injured mice
- D. Bottai, D. Cigognini, L. Madaschi, Raffaella Adami, A. Gorio
- Experimental Neurology
- 1 June 2010
The purpose of this study was to determine the fate and the effects of undifferentiated embryonic stem cells (ESCs) in mice after contusive lesion of the spinal cord (SCI). Reproducible traumatic… Expand
Evaluation of mechanical properties and therapeutic effect of injectable self-assembling hydrogels for spinal cord injury.
- D. Cigognini, D. Silva, Sara Paloppi, F. Gelain
- Materials Science, Medicine
- Journal of biomedical nanotechnology
- 1 February 2014
Self-assembling peptides are promising biomaterials for spinal cord repair as they can easily be injected into the lesion site and can provide physical support to regrowing nervous tissue. However,… Expand
Macromolecular crowding meets oxygen tension in human mesenchymal stem cell culture - A step closer to physiologically relevant in vitro organogenesis
Modular tissue engineering is based on the cells’ innate ability to create bottom-up supramolecular assemblies with efficiency and efficacy still unmatched by man-made devices. Although the… Expand
Third trimester NG2-positive amniotic fluid cells are effective in improving repair in spinal cord injury
- D. Bottai, G. Scesa, D. Cigognini, Raffaella Adami, A. Gorio
- Biology, Medicine
- Experimental Neurology
- 1 April 2014
Spinal cord injury presents a significant therapeutic challenge since the treatments available are mostly vain. The use of stem cells to treat this condition represents a promising new therapeutic… Expand
Third trimester human amniotic fluid cells isolation and phenothypical characterizzation
NG2-positive cells from amniotic fluid ameliorate the functional recovery in a mouse model of spinal cord injury