D. Church

Publications28
h-index13
Citations914
Highly Influential Citations20
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Insulin‐like growth factor ligands, receptors, and binding proteins in cancer
This review aims to summarize experimental evidence supporting the role of the insulin‐like growth factor (IGF) signalling system in the progression, maintenance, and treatment of cancer. These data… Expand
Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.
Prostate cancer is the most common type of cancer in men and ranks second only to lung cancer in cancer-related deaths. The management of locally advanced prostate cancer is difficult because the… Expand
Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.
beta-Lapachone and certain of its derivatives directly bind and inhibit topoisomerase I (Topo I) DNA unwinding activity and form DNA-Topo I complexes, which are not resolvable by SDS-K+ assays. We… Expand
Androgen deprivation induces senescence characteristics in prostate cancer cells in vitro and in vivo
The treatment of non‐localized prostate cancer involves androgen deprivation (AD) therapy which results in tumor regression. Apoptosis has been implicated in the tumor response to AD, but constitutes… Expand
JunD mediates androgen‐induced oxidative stress in androgen dependent LNCaP human prostate cancer cells
Numerous and compelling evidence shows that high level of reactive oxygen species (ROS) plays a key role in prostate cancer occurrence, recurrence and progression. The molecular mechanism of ROS… Expand
Expression of spermidine/spermine N1‐acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis
Prostate cancer (PCa) in many patients remains indolent for the rest of their lives, but in some patients, it progresses to lethal metastatic disease. Gleason score is the current clinical method for… Expand
122 POSTER An inhibitor of acetyl polyamine oxidase specifically blocks androgen induced oxidative stress and prevents occurrence of prostate cancer in TRansgenic Adenocarcinoma of Mouse Prostate…
Growth inhibition and differentiation in human prostate carcinoma cells induced by the vitamin D analog 1α,24‐dihydroxyvitamin D2
Vitamin D has been suggested as a chemopreventive and therapeutic modality for prostate cancer. However, hypercalcemic toxicity has limited the use of 1α,25‐dihydroxyvitamin D3 (1,25‐(OH)2D3) in… Expand
Induction of AP‐1 activity by androgen activation of the androgen receptor in LNCaP human prostate carcinoma cells
The androgen receptor and activator protein‐1 (AP‐1) transcription factors affect growth regulation in normal and cancerous prostate cells. Effects of androgen‐activated androgen receptor on AP‐1… Expand
A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.
High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiologic factor in prostate cancer (CaP) occurrence, recurrence, and progression. Androgen induces… Expand
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