D. Church

Publications29
h-index13
Citations975
Highly Influential Citations23
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Insulin‐like growth factor ligands, receptors, and binding proteins in cancer
TLDR
Experimental evidence supporting the role of the insulin‐like growth factor (IGF) signalling system in the progression, maintenance, and treatment of cancer is summarized.
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Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.
TLDR
It is presented here for the first time that signal transducers and activators of transcription 3 (Stat3), which is constitutively activated in a wide variety of human cancers, including prostate cancer, interacts with PKCepsilon.
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Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.
beta-Lapachone and certain of its derivatives directly bind and inhibit topoisomerase I (Topo I) DNA unwinding activity and form DNA-Topo I complexes, which are not resolvable by SDS-K+ assays. We…
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Androgen deprivation induces senescence characteristics in prostate cancer cells in vitro and in vivo
TLDR
The treatment of non‐localized prostate cancer involves androgen deprivation (AD) therapy which results in tumor regression, and the occurrence of senescence in prostate tumor tissue after AD therapy has not previously been investigated.
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JunD mediates androgen‐induced oxidative stress in androgen dependent LNCaP human prostate cancer cells
TLDR
It is reported that androgen–androgen receptor induced ROS production in androgen‐dependent LNCaP human prostate cancer cells is associated with increased JunD level/AP‐1 transcriptional activity.
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Expression of spermidine/spermine N1‐acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis
TLDR
It is shown that oxidative stress plays a key role in PCa progression and an activation of spermidine/spermine N1‐acetyl transferase initiates a polyamine oxidation pathway and generates copious amounts of reactive oxygen species in polyamine‐rich PCa cells.
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122 POSTER An inhibitor of acetyl polyamine oxidase specifically blocks androgen induced oxidative stress and prevents occurrence of prostate cancer in TRansgenic Adenocarcinoma of Mouse Prostate…
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Growth inhibition and differentiation in human prostate carcinoma cells induced by the vitamin D analog 1α,24‐dihydroxyvitamin D2
TLDR
The less hypercalcemic vitamin D analog 1α, 24‐dihydroxyvitamin D2 (1,24‐(OH)2D2) was examined for its effects on cellular growth inhibition and differentiation induction in the LNCaP human prostate carcinoma cell line.
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Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species
TLDR
The structure of LNM E1 reveals critical new insights into LNM biosynthesis, setting the stage to investigate sulfur incorporation, as well as the tailoring steps that convert the nascent hybrid peptide–polyketide biosynthetic intermediate into L NM.
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Induction of AP‐1 activity by androgen activation of the androgen receptor in LNCaP human prostate carcinoma cells
TLDR
The androgen receptor and activator protein‐1 (AP‐1) transcription factors affect growth regulation in normal and cancerous prostate cells and their effects were determined in the LNCaP human prostate carcinoma cell model.
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