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Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-11C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
A graphical method of analysis applicable to ligands that bind reversibly to receptors or enzymes requiring the simultaneous measurement of plasma and tissue radioactivities for multiple times afterExpand
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Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET.
The regional distributions of monoamine oxidase (MAO) types A and B have been identified in human brain in vivo with intravenously injected 11C-labeled suicide enzyme inactivators, clorgyline andExpand
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Mapping cocaine binding sites in human and baboon brain in vivo
The first direct measurements of cocaine binding in the brain of normal human volunteers and baboons have been made by using positron emission tomography (PET) and tracer doses ofExpand
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Radiopharmaceuticals XXVII. 18F-labeled 2-deoxy-2-fluoro-d-glucose as a radiopharmaceutical for measuring regional myocardial glucose metabolism in vivo: tissue distribution and imaging studies in
18F-2-Deoxy-2-fluoro-D-glucose (18FDG) is rapidly extracted by the mouse heart, and the radioactivity in heart (3-4% per organ) remains relatively constant for 2 hr post injection. The brain uptakeExpand
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Metabolic mapping of functional activity in human subjects with the [18F]fluorodeoxyglucose technique.
The 2-[18F]fluoro-2-deoxy-D-glucose technique was used to measure regional cerebral glucose utilization by human subjects during functional activation. Normal male volunteers subjected to one or moreExpand
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Studies on the Mechanism of Olefin-Alcohol Interconversion. The Effect of Acidity on the O 18 Exchange and Dehydration Rates of t-Alcohols
Evidence from the acidity and temperature dependence of the rates of O18 exchange and dehydration of t-alcohols was obtained; this evidence indicates that these two reactions proceed by commonExpand
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Organic radiopharmaceuticals labeled with isotopes of short half-life. V. 18 F-labeled 5- and 6-fluorotryptophan.
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Increased accumulation of 2-deoxy-2-[18F]Fluoro-D-glucose in liver metastases from colon carcinoma.
Three patients with liver metastases from colon carcinoma were studied with 2-deoxy-2-[F-18]fluoro-d-glucose (F-18-FDG) using positron emission tomography. The radioactivity in the metastatic tumorExpand
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Regional brain glucose metabolism in chronic schizophrenia. A positron emission transaxial tomographic study.
Thirteen diagnosed schizophrenics and 11 normal controls were studied with a method using the PETT III positron emission tomograph (PET) and fluorodeoxyglucose labeled with fluorine 18. Each subjectExpand
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Reproducibility of Cerebral Glucose Metabolic Measurements in Resting Human Subjects
Positron emission tomography with 11C-2-deoxyglucose was used to determine the test-retest variability of regional cerebral glucose metabolism in 22 young normal right-handed men scanned twice in aExpand
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