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Structural biology and chemistry of the terpenoid cyclases.
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HDAC8 mutations in Cornelia de Lange Syndrome affect the cohesin acetylation cycle
Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL for nearly 60% of individuals with classicalExpand
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Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase
The x-ray crystal structure of dimeric (+)-bornyl diphosphate synthase, a metal-requiring monoterpene cyclase from Salvia officinalis, is reported at 2.0-Å resolution. Each monomer contains twoExpand
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Taxadiene Synthase Structure and Evolution of Modular Architecture in Terpene Biosynthesis
With more than 55,000 members identified so far in all forms of life, the family of terpene or terpenoid natural products represents the epitome of molecular biodiversity. A well-known and importantExpand
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Structure of a unique binuclear manganese cluster in arginase
EACH individual excretes roughly 10 kg of urea per year, as a result of the hydrolysis of arginine in the final cytosolic step of the urea cycle1. This reaction allows the disposal of nitrogenousExpand
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Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells
Overexpression of the zinc enzyme carbonic anhydrase (CA; EC 4.2.1.1) XII is observed in certain human cancers. This bitopic membrane protein contains an N-terminal extracellular catalytic domain, aExpand
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Ribonuclease P protein structure: evolutionary origins in the translational apparatus.
The crystal structure of Bacillus subtilis ribonuclease P protein is reported at 2.6 angstroms resolution. This protein binds to ribonuclease P RNA to form a ribonucleoprotein holoenzyme with optimalExpand
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Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology.
The crystal structure of pentalenene synthase at 2.6 angstrom resolution reveals critical active site features responsible for the cyclization of farnesyl diphosphate into the tricyclic hydrocarbonExpand
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Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.
There is increasing evidence that upregulation of arginase contributes to impaired endothelial function in aging. In this study, we demonstrate that arginase upregulation leads to endothelial nitricExpand
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Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade
The x-ray crystal structure of recombinant trichodiene synthase from Fusarium sporotrichioides has been determined to 2.5-Å resolution, both unliganded and complexed with inorganic pyrophosphate.Expand
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