• Publications
  • Influence
Highly Nonrandom Features of Synaptic Connectivity in Local Cortical Circuits
TLDR
We probed synaptic connections with several hundred simultaneous quadruple whole-cell recordings from layer 5 pyramidal neurons in the rat visual cortex and found several nonrandom features in synaptic connectivity. Expand
  • 1,258
  • 136
  • PDF
A visual motion detection circuit suggested by Drosophila connectomics
Animal behaviour arises from computations in neuronal circuits, but our understanding of these computations has been frustrated by the lack of detailed synaptic connection maps, or connectomes. ForExpand
  • 535
  • 49
  • PDF
Structural Properties of the Caenorhabditis elegans Neuronal Network
TLDR
We assemble whole, self-consistent gap junction and chemical synapse networks of hermaphrodite Caenorhabditis elegans. Expand
  • 646
  • 44
  • PDF
Wiring optimization can relate neuronal structure and function.
We pursue the hypothesis that neuronal placement in animals minimizes wiring costs for given functional constraints, as specified by synaptic connectivity. Using a newly compiled version of theExpand
  • 503
  • 37
  • PDF
Ultrastructural Analysis of Hippocampal Neuropil from the Connectomics Perspective
Complete reconstructions of vertebrate neuronal circuits on the synaptic level require new approaches. Here, serial section transmission electron microscopy was automated to densely reconstruct fourExpand
  • 241
  • 25
  • PDF
Geometry and Structural Plasticity of Synaptic Connectivity
Changes in synaptic connectivity patterns through the formation and elimination of dendritic spines may contribute to structural plasticity in the brain. We characterize this contributionExpand
  • 290
  • 22
  • PDF
Cortical rewiring and information storage
Current thinking about long-term memory in the cortex is focused on changes in the strengths of connections between neurons. But ongoing structural plasticity in the adult brain, including synapseExpand
  • 667
  • 21
  • PDF
Proprioceptive Coupling within Motor Neurons Drives C. elegans Forward Locomotion
Locomotion requires coordinated motor activity throughout an animal's body. In both vertebrates and invertebrates, chains of coupled central pattern generators (CPGs) are commonly evoked to explainExpand
  • 194
  • 17
  • PDF
Geometric and functional organization of cortical circuits
Can neuronal morphology predict functional synaptic circuits? In the rat barrel cortex, 'barrels' and 'septa' delineate an orderly matrix of cortical columns. Using quantitative laser scanningExpand
  • 234
  • 15
  • PDF
The comprehensive connectome of a neural substrate for ‘ON’ motion detection in Drosophila
TLDR
We reconstructed a comprehensive connectome of the circuits of Drosophila‘s motion-sensing T4 cells using a novel EM technique. Expand
  • 108
  • 15