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Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25.
TLDR
The results demonstrate that the AMPKK activity of LKB1/STRAD/MO25 is substrate specific and distinct from the kinase activity of SOTA, and demonstrate that long-chain acyl-CoA esters inhibited phosphorylation of AMPK by the recombinant AMPK kinase (AMPKK) L KB1/ STRAD/ MO25 in a concentration-dependent manner. Expand
Endurance training increases skeletal muscle LKB1 and PGC-1alpha protein abundance: effects of time and intensity.
TLDR
It is demonstrated that LKB1 and PGC-1alpha protein abundances increase with endurance and interval training similarly to citrate synthase, which may function to maintain the training-induced increases in mitochondrial mass. Expand
Evidence against regulation of AMP-activated protein kinase and LKB1/STRAD/MO25 activity by creatine phosphate.
TLDR
It is found that creatine phosphate did not inhibit phosphorylation of either recombinant or purified rat liver AMPK by LKB1, and Creatine phosphate may indirectly modulate AMPK activity by replenishing ATP at the onset of muscle contraction. Expand
Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25.
TLDR
3-PG is identified as an AMPK-specific regulator of AMPK phosphorylation and activation by LKB1-STRAD-MO25 during skeletal muscle contraction, and may be regulated by allosteric mechanisms. Expand
Effects of Endurance Training on the AMPK Response to Exercise.
TLDR
This research presents a meta-analysis of the impact of physical activity training on the response of the immune system to exercise and suggests that exercise-based approaches to immunity are more beneficial than other approaches. Expand