• Publications
  • Influence
Hepatitis B e antigen and the risk of hepatocellular carcinoma.
BACKGROUND The presence of hepatitis B e antigen (HBeAg) in serum indicates active viral replication in hepatocytes. HBeAg is thus a surrogate marker for the presence of hepatitis B virus DNA. WeExpand
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Associations Between Hepatitis B Virus Genotype and Mutants and the Risk of Hepatocellular Carcinoma
Background The risk of hepatocellular carcinoma (HCC) increases with increasing level of hepatitis B virus (HBV) in serum (viral load). However, it is unclear whether genetic characteristics of HBV,Expand
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Global control of hepatitis B virus infection.
  • J. Kao, D. Chen
  • Biology, Medicine
  • The Lancet. Infectious diseases
  • 1 July 2002
Worldwide about 350 million people are chronic carriers of the hepatitis B virus (HBV). The infection can cause acute and chronic liver disease including cirrhosis and hepatocellular carcinoma (HCC).Expand
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Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men.
BACKGROUND Although chronic infection with hepatitis B virus (HBV) has been established as a cause of hepatocellular carcinoma (HCC), the roles of viral load and HBV genotype remain unclear. Expand
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Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study.
BACKGROUND Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma. This population-based study aimed to investigate whether prevention of hepatocellular carcinoma by theExpand
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An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection
An animal model for human hepatitis B virus (HBV) tolerance is needed to investigate the mechanisms. This model will also facilitate therapeutic strategies for the existing 350 million patients withExpand
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Two decades of universal hepatitis B vaccination in taiwan: impact and implication for future strategies.
BACKGROUND & AIMS Following the world's first successful implementation of a universal hepatitis B virus (HBV) vaccination program for infants in Taiwan 20 years ago, we performed this study toExpand
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Minimization of hepatitis B infection by a 25-year universal vaccination program.
BACKGROUND & AIMS Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984. FiveExpand
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The small delta antigen of hepatitis delta virus is an acetylated protein and acetylation of lysine 72 may influence its cellular localization and viral RNA synthesis.
Hepatitis delta virus (HDV) is a single-stranded RNA virus that encodes two viral nucleocapsid proteins named small and large form hepatitis delta antigen (S-HDAg and L-HDAg). The S-HDAg is essentialExpand
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Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B.
  • D. Chen
  • Medicine
  • Journal of hepatology
  • 1 April 2009
Hepatitis B virus infection is a global health problem. Worldwide, about 360 million people are chronically infected with the virus. They continue to spread the virus to others and are themselves atExpand
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